GABA-Induced Intracellular Mg                         2+                          Mobilization Integrates and Coordinates Cellular Information Processing for the Maturation of Neural Networks

Ryu Yamanaka; Yutaka Shindo; Kohji Hotta; Koji Suzuki; Kotaro Oka

doi:10.1016/j.cub.2018.10.044

GABA-Induced Intracellular Mg ²⁺ Mobilization Integrates and Coordinates Cellular Information Processing for the Maturation of Neural Networks

Ryu Yamanaka, Yutaka Shindo, Kohji Hotta, Koji Suzuki, Kotaro Oka

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Yamanaka et al. demonstrate that GABA triggers mitochondrial Mg ²⁺ release in neurons at specifically developmental early stages, and the physiological Mg ²⁺ redistribution into cytoplasm regulates ERK, CREB, and mTOR activities with target-dependent manners, thereby facilitating neuronal maturation. Mg ²⁺ is a novel signal transducer.

Original language	English
Pages (from-to)	3984-3991.e5
Journal	Current Biology
Volume	28
Issue number	24
DOIs	https://doi.org/10.1016/j.cub.2018.10.044
Publication status	Published - 2018 Dec 17

Keywords

GABA
cellular information processing
magnesium ion
neuronal development
signal transduction

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

Access to Document

10.1016/j.cub.2018.10.044

Cite this

Yamanaka, R., Shindo, Y., Hotta, K., Suzuki, K., & Oka, K. (2018). GABA-Induced Intracellular Mg ²⁺ Mobilization Integrates and Coordinates Cellular Information Processing for the Maturation of Neural Networks Current Biology, 28(24), 3984-3991.e5. https://doi.org/10.1016/j.cub.2018.10.044

GABA-Induced Intracellular Mg ²⁺ Mobilization Integrates and Coordinates Cellular Information Processing for the Maturation of Neural Networks . / Yamanaka, Ryu; Shindo, Yutaka ; Hotta, Kohji et al.
In: Current Biology, Vol. 28, No. 24, 17.12.2018, p. 3984-3991.e5.

Research output: Contribution to journal › Article › peer-review

Yamanaka, R, Shindo, Y , Hotta, K, Suzuki, K & Oka, K 2018, ' GABA-Induced Intracellular Mg ²⁺ Mobilization Integrates and Coordinates Cellular Information Processing for the Maturation of Neural Networks ', Current Biology, vol. 28, no. 24, pp. 3984-3991.e5. https://doi.org/10.1016/j.cub.2018.10.044

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