Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer

Pablo Argüeso; Jerome Mauris; Yuichi Uchino

doi:10.1080/21688370.2015.1026505

Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer

Pablo Argüeso, Jerome Mauris, Yuichi Uchino

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Tissue Barriers
Volume	3
Issue number	3
DOIs	https://doi.org/10.1080/21688370.2015.1026505
Publication status	Published - 2015 Jul 3
Externally published	Yes

Keywords

cancer
epithelial junction
galectin-3
matrix metalloproteinases
wound healing

ASJC Scopus subject areas

Biochemistry
Histology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/21688370.2015.1026505

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abstract = "Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.",

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AU - Argüeso, Pablo

AU - Mauris, Jerome

AU - Uchino, Yuichi

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AB - Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.

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KW - matrix metalloproteinases

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Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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