Gallbladder carcinoma with osteoclast-like giant cells

Tomotaka Akatsu, Kaori Kameyama, Shigeyuki Kawachi, Minoru Tanabe, Koichi Aiura, Go Wakabayashi, Masakazu Ueda, Motohide Shimazu, Masaki Kitajima

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Extraskeletal tumors containing multinucleated, osteoclast-like giant cells (OGCs) are uncommon. These neoplasms are most frequently reported in the breast and pancreas. Recently, some authors have suggested that carcinomas containing OGCs may represent a distinct clinicopathological entity with a more favorable prognosis. Occurrence in the gallbladder is extremely rare, with only one previous case. We report here on an additional case of gallbladder carcinoma with an infiltrate of OGCs. A 72-year-old woman presented with postprandial abdominal pain and was found to have a mass in the body of the gallbladder with direct liver invasion. Histological examination showed an adenosquamous carcinoma with an infiltrate of benign OGCs. Immunohistochemical analysis demonstrated that the giant cells were of histiocytic origin. The patient survived for 6 years without evidence of recurrence. This case adds to a small body of literature on gallbladder carcinoma with OGCs. Further studies are required to clearly define the prognostic significance of these giant cells in gallbladder cancer and the differences between adenosquamous carcinoma with OGCs and other gallbladder carcinomas (such as adenocarcinoma and squamous cell carcinoma) with those cells.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalJournal of gastroenterology
Issue number1
Publication statusPublished - 2006 Jan 1


  • Adenosquamous carcinoma
  • Gallbladder cancer
  • Osteoclast-like giant cell

ASJC Scopus subject areas

  • Gastroenterology


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