Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice

Chiyoko Nishime, Yasuyuki Ohnishi, Hiroshi Suemizu, Norikazu Tamaoki, Makoto Suematsu, Yasuhisa Oida, Hitoshi Yamazaki, Masato Nakamura, Yoshito Ueyama, Hiroshi Kijima

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The GB-04-JCK xenograft line of human gallbladder small cell carcinoma was established in nude mice by serial transplantation. The xenotransplantability has been maintained for more than 20 years. The carcinoma cells grew in a solid-sheet pattern and were found to have hyperchromatic nuclei, finely dispersed chromatin and inconspicuous nucleoli in the primary gallbladder tumor, as well as in the established xenograft GB-04-JCK. The carcinoma cells also had Grimelius argyrophil granules, electron-dense neuroendocrine granules bounded by a single membrane. The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalAnticancer research
Issue number1 A
Publication statusPublished - 2006 Jan
Externally publishedYes


  • Gallbladder cancer
  • Immunohistochemistry
  • Small cell carcinoma
  • Xenograft

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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