Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins

Takumi Yamaguchi; Tsuyoshi Uno; Yoshinori Uekusa; Maho Yagi-Utsumi; Koichi Kato

doi:10.1039/c2cc38016a

Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins

Takumi Yamaguchi, Tsuyoshi Uno, Yoshinori Uekusa, Maho Yagi-Utsumi, Koichi Kato

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidogenic proteins. This enabled probing of initial membrane-landing processes of α-synuclein as a therapeutic target by NMR spectroscopy.

Original language	English
Pages (from-to)	1235-1237
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	12
DOIs	https://doi.org/10.1039/c2cc38016a
Publication status	Published - 2013 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc38016a

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abstract = "We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidogenic proteins. This enabled probing of initial membrane-landing processes of α-synuclein as a therapeutic target by NMR spectroscopy.",

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AU - Yagi-Utsumi, Maho

AU - Kato, Koichi

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Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins

Abstract

ASJC Scopus subject areas

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