Gastrointestinal stromal tumor presenting with prominent calcification

Naoki Izawa, Takeshi Sawada, Ryuichi Abiko, Daisuke Kumon, Mami Hirakawa, Mika Kobayashi, Nobuyuki Obinata, Masahito Nomoto, Tadateru Maehata, Shun Ichi Yamauchi, Takefumi Kouro, Takashi Tsuda, Satoshi Kitajima, Hiroshi Yasuda, Keiichi Tanaka, Ichiro Tanaka, Masahiro Hoshikawa, Masayuki Takagi, Fumio Itoh

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcification at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindleshaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to KIT and CD34 and a low mitotic index resulted in the diagnosis of very low risk GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism.

Original languageEnglish
Pages (from-to)5645-5648
Number of pages4
JournalWorld Journal of Gastroenterology
Issue number39
Publication statusPublished - 2012
Externally publishedYes


  • Calcification
  • Computed tomography
  • Gastrointestinal stromal tumor
  • Imatinib mesylate
  • Stomach

ASJC Scopus subject areas

  • Gastroenterology


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