Gene therapy for breast cancer. — review of clinical gene therapy trials for breast cancer and mdr1 gene therapy trial in cancer institute hospital

Shunji Takahashi, Yoshinori Ito, Kiyohiko Hatake, Yoshikazu Sugimoto

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)

Abstract

Gene therapy for advanced breast cancer is anticipated to be a useful therapeutic approach. Strategies in ongoing clinical protocols can be divided into four groups: (1) suppression of oncogenes or transfer of tumor-suppressor genes; (2) enhancement of immunological response; (3) transfer of suicide genes; (4) protection of bone marrow using drug resistance genes. We have started a clinical study of multidrug resistance (MDRl) gene therapy. Advanced breast cancer patients received high dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT) withMDRl-transduced hematopoietic cells, and then were treated with docetaxel. Two patients have been treated so far, andin vivo enrichment ofMDRl-transduced cells with docetaxel treatment has been seen. Both patients are in complete remission and had no apparent adverse effects from theMDRl gene transfer.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalBreast Cancer
Volume13
Issue number1
DOIs
Publication statusPublished - 2006 Jan

Keywords

  • Adenoviral vector
  • Breast cancer
  • Gene therapy
  • MDRl
  • Retroviral vector

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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