Genes highly expressed in the early phase of murine graft-versus-host reaction

Masatoshi Wakui, Daisuke Sakurai, Naoyuki Tsuchiya, Katsushi Tokunaga, Masatoshi Wakui, Yasuo Ikeda, Akihiro Yamaguchi, Kouetsu Ogasawara, Taeko Yokochi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Graft-versus-host reaction (GVHR) is a complex process initiated upon allorecognition. For detection of early molecular events in GVHR, we first assessed time courses with respect to symptoms and serum interferon (IFN)-γ levels and then used the differential display method to compare gene transcript patterns during the early phase between acute lethal GVHR mice and syngeneic controls. In the GVHR mice, high expression levels of seven genes encoding the following molecules were detected: TGTP/Mg21 (an IFN-γ-related signaling molecule), vitronectin, Nedd5 (a mammalian septin), manganese superoxide dismutase, activin βC subunit, PRCC (a papillary renal cell carcinoma-associated molecule), and an uncharacterized gene corresponding to a mouse expressed sequence tag (EST). The expression levels of most genes peaked before the symptomatological onset and the peak of IFN-γ levels. Thus, gene expression monitoring may characterize the inductive process of GVHR and aid in the development of gene-based diagnostics and therapies.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - 2001
Externally publishedYes


  • Activin βC subunit
  • Differential display method
  • Early phase
  • Gene expression
  • Graft-versus-host reaction
  • Manganese superoxide dismutase
  • Nedd5
  • PRCC
  • TGTP/Mg21
  • Vitronectin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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