Genetic Protective Factors for Dementia Isolated by Centenarian Researches

Research output: Contribution to journalReview articlepeer-review


Due to the recent rapid increase in the number of elderly people in the world, health management and maintenance in elderly people have become important issues. Centenaria, who are older than 100 years, tend to stay independent in their daily life with maintenance of cognitive function until the later stage of their life compared with elderly people who die earlier. In this review, we summarize the characteristics of centenarians, the genetic risk and protective factors for longevity, and intersections between research on centenarians and dementia research.

Original languageEnglish
Pages (from-to)1061-1070
Number of pages10
JournalBrain and nerve = Shinkei kenkyu no shinpo
Issue number10
Publication statusPublished - 2019 Oct 1

ASJC Scopus subject areas

  • Clinical Neurology


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