Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus

Shiro Maeda; Shuichi Tsukada; Akio Kanazawa; Akihiro Sekine; Tatsuhiko Tsunoda; Daisuke Koya; Hiroshi Maegawa; Atsunori Kashiwagi; Tetsuya Babazono; Masafumi Matsuda; Yasushi Tanaka; Tomoaki Fujioka; Hiroshi Hirose; Takashi Eguchi; Yoichi Ohno; Christopher J. Groves; Andrew T. Hattersley; Graham A. Hitman; Mark Walker; Kohei Kaku; Yasuhiko Iwamoto; Ryuzo Kawamori; Ryuichi Kikkawa; Naoyuki Kamatani; Mark I. McCarthy; Yusuke Nakamura

doi:10.1007/s10038-005-0253-9

Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus

Shiro Maeda, Shuichi Tsukada, Akio Kanazawa, Akihiro Sekine, Tatsuhiko Tsunoda, Daisuke Koya, Hiroshi Maegawa, Atsunori Kashiwagi, Tetsuya Babazono, Masafumi Matsuda, Yasushi Tanaka, Tomoaki Fujioka, Hiroshi Hirose, Takashi Eguchi, Yoichi Ohno, Christopher J. Groves, Andrew T. Hattersley, Graham A. Hitman, Mark Walker, Kohei KakuYasuhiko Iwamoto, Ryuzo Kawamori, Ryuichi Kikkawa, Naoyuki Kamatani, Mark I. McCarthy, Yusuke Nakamura

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Abstract

To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor- activating protein 2β (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: χ²=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20-2.06, intron 1+774 (G/T); χ²=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22-2.09, intron 1+2093 (A/C); χ²=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23-2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.

Original language	English
Pages (from-to)	283-292
Number of pages	10
Journal	Journal of Human Genetics
Volume	50
Issue number	6
DOIs	https://doi.org/10.1007/s10038-005-0253-9
Publication status	Published - 2005 Aug

Keywords

Adipocytes
Association study
Single nucleotide polymorphism (SNP)
Type 2 diabetes
Variable number of tandem repeats (VNTR)

ASJC Scopus subject areas

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10038-005-0253-9

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Maeda, S., Tsukada, S., Kanazawa, A., Sekine, A., Tsunoda, T., Koya, D., Maegawa, H., Kashiwagi, A., Babazono, T., Matsuda, M., Tanaka, Y., Fujioka, T., Hirose, H., Eguchi, T., Ohno, Y., Groves, C. J., Hattersley, A. T., Hitman, G. A., Walker, M., ... Nakamura, Y. (2005). Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. Journal of Human Genetics, 50(6), 283-292. https://doi.org/10.1007/s10038-005-0253-9

Maeda, S, Tsukada, S, Kanazawa, A, Sekine, A, Tsunoda, T, Koya, D, Maegawa, H, Kashiwagi, A, Babazono, T, Matsuda, M, Tanaka, Y, Fujioka, T, Hirose, H, Eguchi, T, Ohno, Y, Groves, CJ, Hattersley, AT, Hitman, GA, Walker, M, Kaku, K, Iwamoto, Y, Kawamori, R, Kikkawa, R, Kamatani, N, McCarthy, MI & Nakamura, Y 2005, 'Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus', Journal of Human Genetics, vol. 50, no. 6, pp. 283-292. https://doi.org/10.1007/s10038-005-0253-9

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title = "Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus",

abstract = "To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor- activating protein 2β (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: χ2=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20-2.06, intron 1+774 (G/T); χ2=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22-2.09, intron 1+2093 (A/C); χ2=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23-2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.",

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year = "2005",

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doi = "10.1007/s10038-005-0253-9",

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T1 - Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus

AU - Maeda, Shiro

AU - Tsukada, Shuichi

AU - Kanazawa, Akio

AU - Sekine, Akihiro

AU - Tsunoda, Tatsuhiko

AU - Koya, Daisuke

AU - Maegawa, Hiroshi

AU - Kashiwagi, Atsunori

AU - Babazono, Tetsuya

AU - Matsuda, Masafumi

AU - Tanaka, Yasushi

AU - Fujioka, Tomoaki

AU - Hirose, Hiroshi

AU - Eguchi, Takashi

AU - Ohno, Yoichi

AU - Groves, Christopher J.

AU - Hattersley, Andrew T.

AU - Hitman, Graham A.

AU - Walker, Mark

AU - Kaku, Kohei

AU - Iwamoto, Yasuhiko

AU - Kawamori, Ryuzo

AU - Kikkawa, Ryuichi

AU - Kamatani, Naoyuki

AU - McCarthy, Mark I.

AU - Nakamura, Yusuke

PY - 2005/8

Y1 - 2005/8

N2 - To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor- activating protein 2β (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: χ2=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20-2.06, intron 1+774 (G/T); χ2=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22-2.09, intron 1+2093 (A/C); χ2=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23-2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.

AB - To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor- activating protein 2β (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: χ2=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20-2.06, intron 1+774 (G/T); χ2=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22-2.09, intron 1+2093 (A/C); χ2=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23-2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.

KW - Adipocytes

KW - Association study

KW - Single nucleotide polymorphism (SNP)

KW - Type 2 diabetes

KW - Variable number of tandem repeats (VNTR)

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Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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