Genome-wide association study for adolescent idiopathic scoliosis

Japan Scoliosis Clinical Research Group

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


Adolescent idiopathic scoliosis(AIS)is a polygenic disease. Genome-wide association studies(GWASs)have been performed for a lot of polygenic diseases. For AIS, we conducted GWAS and identified the first AIS locus near LBX1. After the discovery, we have extended our study by increasing the numbers of subjects and SNPs. In total, our Japanese GWAS has identified four susceptibility genes. GWASs for AIS have also been performed in the USA and China, which identified one and three susceptibility genes, respectively. Here we review GWASs in Japan and abroad and functional analysis to clarify the pathomechanism of AIS.

Original languageEnglish
Pages (from-to)553-560
Number of pages8
JournalClinical calcium
Issue number4
Publication statusPublished - 2016 Apr 1

ASJC Scopus subject areas

  • General Medicine


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