Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations

Emiko Noguchi; Hiromi Sakamoto; Tomomitsu Hirota; Kaori Ochiai; Yoshimasa Imoto; Masafumi Sakashita; Fumitake Kurosaka; Akira Akasawa; Shigemi Yoshihara; Noriko Kanno; Yumi Yamada; Naoki Shimojo; Yoichi Kohno; Yoichi Suzuki; Mi Jin Kang; Ji Won Kwon; Soo Jong Hong; Ken Inoue; Yu Ichi Goto; Fumio Yamashita; Takashi Asada; Hiroshi Hirose; Ikuo Saito; Shigeharu Fujieda; Nobuyuki Hizawa; Toru Sakamoto; Hironori Masuko; Yusuke Nakamura; Ichiro Nomura; Mayumi Tamari; Tadao Arinami; Teruhiko Yoshida; Hirohisa Saito; Kenji Matsumoto

doi:10.1371/journal.pgen.1002170

Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations

Emiko Noguchi, Hiromi Sakamoto, Tomomitsu Hirota, Kaori Ochiai, Yoshimasa Imoto, Masafumi Sakashita, Fumitake Kurosaka, Akira Akasawa, Shigemi Yoshihara, Noriko Kanno, Yumi Yamada, Naoki Shimojo, Yoichi Kohno, Yoichi Suzuki, Mi Jin Kang, Ji Won Kwon, Soo Jong Hong, Ken Inoue, Yu Ichi Goto, Fumio YamashitaTakashi Asada, Hiroshi Hirose, Ikuo Saito, Shigeharu Fujieda, Nobuyuki Hizawa, Toru Sakamoto, Hironori Masuko, Yusuke Nakamura, Ichiro Nomura, Mayumi Tamari, Tadao Arinami, Teruhiko Yoshida, Hirohisa Saito, Kenji Matsumoto

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Abstract

Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10 ^-8) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P _combined = 2.3×10 ^-10, odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10 ^-10, OR = 1.52, and DPB1*0901: P = 2.0×10 ^-7, OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.

Original language	English
Article number	e1002170
Journal	PLoS Genetics
Volume	7
Issue number	7
DOIs	https://doi.org/10.1371/journal.pgen.1002170
Publication status	Published - 2011 Jul

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Genetics(clinical)
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Noguchi, E., Sakamoto, H., Hirota, T., Ochiai, K., Imoto, Y., Sakashita, M., Kurosaka, F., Akasawa, A., Yoshihara, S., Kanno, N., Yamada, Y., Shimojo, N., Kohno, Y., Suzuki, Y., Kang, M. J., Kwon, J. W., Hong, S. J., Inoue, K., Goto, Y. I., ... Matsumoto, K. (2011). Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genetics, 7(7), Article e1002170. https://doi.org/10.1371/journal.pgen.1002170

Noguchi, E, Sakamoto, H, Hirota, T, Ochiai, K, Imoto, Y, Sakashita, M, Kurosaka, F, Akasawa, A, Yoshihara, S, Kanno, N, Yamada, Y, Shimojo, N, Kohno, Y, Suzuki, Y, Kang, MJ, Kwon, JW, Hong, SJ, Inoue, K, Goto, YI, Yamashita, F, Asada, T, Hirose, H, Saito, I, Fujieda, S, Hizawa, N, Sakamoto, T, Masuko, H, Nakamura, Y, Nomura, I, Tamari, M, Arinami, T, Yoshida, T, Saito, H & Matsumoto, K 2011, 'Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations', PLoS Genetics, vol. 7, no. 7, e1002170. https://doi.org/10.1371/journal.pgen.1002170

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title = "Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations",

abstract = "Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10 -8) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P combined = 2.3×10 -10, odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10 -10, OR = 1.52, and DPB1*0901: P = 2.0×10 -7, OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.",

author = "Emiko Noguchi and Hiromi Sakamoto and Tomomitsu Hirota and Kaori Ochiai and Yoshimasa Imoto and Masafumi Sakashita and Fumitake Kurosaka and Akira Akasawa and Shigemi Yoshihara and Noriko Kanno and Yumi Yamada and Naoki Shimojo and Yoichi Kohno and Yoichi Suzuki and Kang, {Mi Jin} and Kwon, {Ji Won} and Hong, {Soo Jong} and Ken Inoue and Goto, {Yu Ichi} and Fumio Yamashita and Takashi Asada and Hiroshi Hirose and Ikuo Saito and Shigeharu Fujieda and Nobuyuki Hizawa and Toru Sakamoto and Hironori Masuko and Yusuke Nakamura and Ichiro Nomura and Mayumi Tamari and Tadao Arinami and Teruhiko Yoshida and Hirohisa Saito and Kenji Matsumoto",

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AU - Noguchi, Emiko

AU - Sakamoto, Hiromi

AU - Hirota, Tomomitsu

AU - Ochiai, Kaori

AU - Imoto, Yoshimasa

AU - Sakashita, Masafumi

AU - Kurosaka, Fumitake

AU - Akasawa, Akira

AU - Yoshihara, Shigemi

AU - Kanno, Noriko

AU - Yamada, Yumi

AU - Shimojo, Naoki

AU - Kohno, Yoichi

AU - Suzuki, Yoichi

AU - Kang, Mi Jin

AU - Kwon, Ji Won

AU - Hong, Soo Jong

AU - Inoue, Ken

AU - Goto, Yu Ichi

AU - Yamashita, Fumio

AU - Asada, Takashi

AU - Hirose, Hiroshi

AU - Saito, Ikuo

AU - Fujieda, Shigeharu

AU - Hizawa, Nobuyuki

AU - Sakamoto, Toru

AU - Masuko, Hironori

AU - Nakamura, Yusuke

AU - Nomura, Ichiro

AU - Tamari, Mayumi

AU - Arinami, Tadao

AU - Yoshida, Teruhiko

AU - Saito, Hirohisa

AU - Matsumoto, Kenji

PY - 2011/7

Y1 - 2011/7

N2 - Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10 -8) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P combined = 2.3×10 -10, odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10 -10, OR = 1.52, and DPB1*0901: P = 2.0×10 -7, OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.

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Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations

Abstract

ASJC Scopus subject areas

UN SDGs

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