Germacranolides from Enhydra fluctuans with TRAIL-resistance abrogating activity

Firoj Ahmed; Utpal K. Karmakar; Midori A. Arai; Naoki Ishikawa; Samir K. Sadhu; Masami Ishibashi

doi:10.1177/1934578x1701200805

Germacranolides from Enhydra fluctuans with TRAIL-resistance abrogating activity

Firoj Ahmed, Utpal K. Karmakar, Midori A. Arai, Naoki Ishikawa, Samir K. Sadhu, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

TRAIL selectively kills cancer cells without harming most normal cells. However, TRAIL resistance is a major problem for its therapeutic use. Developing a strategy to overcome resistance is crucial for the successful use of TRAIL as an antitumor agent. In our screening program of natural products that can abrogate TRAIL resistance, four germacranolides (1-4) were isolated from the aerial parts of Enhydra fluctuans. All compounds exhibited potent TRAILresistance overcoming activity against TRAIL-resistant human gastric adenocarcinoma (AGS) cells.

Original language	English
Pages (from-to)	1169-1170
Number of pages	2
Journal	Natural product communications
Volume	12
Issue number	8
DOIs	https://doi.org/10.1177/1934578x1701200805
Publication status	Published - 2017 Aug
Externally published	Yes

Keywords

Enhydra fluctuans
TRAIL-resistance overcoming activity

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578x1701200805

Cite this

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title = "Germacranolides from Enhydra fluctuans with TRAIL-resistance abrogating activity",

abstract = "TRAIL selectively kills cancer cells without harming most normal cells. However, TRAIL resistance is a major problem for its therapeutic use. Developing a strategy to overcome resistance is crucial for the successful use of TRAIL as an antitumor agent. In our screening program of natural products that can abrogate TRAIL resistance, four germacranolides (1-4) were isolated from the aerial parts of Enhydra fluctuans. All compounds exhibited potent TRAILresistance overcoming activity against TRAIL-resistant human gastric adenocarcinoma (AGS) cells.",

keywords = "Enhydra fluctuans, TRAIL-resistance overcoming activity",

author = "Firoj Ahmed and Karmakar, {Utpal K.} and Arai, {Midori A.} and Naoki Ishikawa and Sadhu, {Samir K.} and Masami Ishibashi",

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month = aug,

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T1 - Germacranolides from Enhydra fluctuans with TRAIL-resistance abrogating activity

AU - Ahmed, Firoj

AU - Karmakar, Utpal K.

AU - Arai, Midori A.

AU - Ishikawa, Naoki

AU - Sadhu, Samir K.

AU - Ishibashi, Masami

PY - 2017/8

Y1 - 2017/8

N2 - TRAIL selectively kills cancer cells without harming most normal cells. However, TRAIL resistance is a major problem for its therapeutic use. Developing a strategy to overcome resistance is crucial for the successful use of TRAIL as an antitumor agent. In our screening program of natural products that can abrogate TRAIL resistance, four germacranolides (1-4) were isolated from the aerial parts of Enhydra fluctuans. All compounds exhibited potent TRAILresistance overcoming activity against TRAIL-resistant human gastric adenocarcinoma (AGS) cells.

AB - TRAIL selectively kills cancer cells without harming most normal cells. However, TRAIL resistance is a major problem for its therapeutic use. Developing a strategy to overcome resistance is crucial for the successful use of TRAIL as an antitumor agent. In our screening program of natural products that can abrogate TRAIL resistance, four germacranolides (1-4) were isolated from the aerial parts of Enhydra fluctuans. All compounds exhibited potent TRAILresistance overcoming activity against TRAIL-resistant human gastric adenocarcinoma (AGS) cells.

KW - Enhydra fluctuans

KW - TRAIL-resistance overcoming activity

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DO - 10.1177/1934578x1701200805

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ER -

Germacranolides from Enhydra fluctuans with TRAIL-resistance abrogating activity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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