Ghrelin and oxidative stress in gastrointestinal tract

Hidekazu Suzuki, Juntaro Matsuzaki, Toshifumi Hibi

Research output: Contribution to journalReview articlepeer-review

63 Citations (Scopus)


Oxidative stress is a major cause of the gastrointestinal damage under physical or psychological stress. Ghrelin exhibits gastroprotective effects and they are supposed to be derived from antioxidant effects. In gastroduodenal mucosal injury, the plasma ghrelin levels increase in response to the demand for gastroduodenal cytoprotection. However, in the condition of Helicobacter pylori-induced gastric mucosal severe atrophy, the plasma ghrelin concentration shifted to lower levels. In diabetic gastroparesis, the regulation of ghrelin secretion is impaired with vagal nerve dysfunction. Selective ghrelin agonist is expected to represent a new class of prokinetic agent. In addition, the plasma ghrelin levels are also enhanced by systemic oxidative stress, and ghrelin exhibits antioxidant effects in many organs, such as heart, pancreas, and lung. This suggests that ghrelin would be an important player as a sensor of systemic oxidative stress.

Original languageEnglish
Pages (from-to)122-125
Number of pages4
JournalJournal of Clinical Biochemistry and Nutrition
Issue number2
Publication statusPublished - 2011 Mar


  • Gastroparesis
  • Ghrelin
  • Oxidative stress
  • Peptic ulcer

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry


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