Giant cell tumors of the clivus: Case report and literature review

Shunsuke Shibao, Masahiro Toda, Kazunari Yoshida

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Background: Clival giant cell tumors (GCTs) are extremely rare with only eight cases reported to date, and malignant transformation is quite rare. Herein, we report a case of an uncontrolled clival GCT, which was transformed malignant, and review the literature. Case Description: A 25-year-old man experienced double vision for 1 month. Computed tomography and magnetic resonance imaging revealed a clival tumor. The endonasal endoscopic transsphenoidal approach (EEA) was used, and partial resection was performed because of massive bleeding. Histological examination showed a GCT. After radiation therapy, the tumor recurred; the EEA and the anterior transpetrosal approaches were used to perform second and third operations, respectively. The MIB-1 index increased from 4.2% to 26.3%. Conclusions: GCTs are difficult to treat because of their location, vascularity, and the potential for malignant transformation.

Original languageEnglish
Pages (from-to)S623-S627
JournalSurgical Neurology International
Publication statusPublished - 2015 Nov 1


  • Clivus
  • giant cell tumor
  • malignant transformation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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