TY - JOUR
T1 - Giant cell tumors of the clivus
T2 - Case report and literature review
AU - Shibao, Shunsuke
AU - Toda, Masahiro
AU - Yoshida, Kazunari
N1 - Publisher Copyright:
© 2015 Surgical Neurology International.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Background: Clival giant cell tumors (GCTs) are extremely rare with only eight cases reported to date, and malignant transformation is quite rare. Herein, we report a case of an uncontrolled clival GCT, which was transformed malignant, and review the literature. Case Description: A 25-year-old man experienced double vision for 1 month. Computed tomography and magnetic resonance imaging revealed a clival tumor. The endonasal endoscopic transsphenoidal approach (EEA) was used, and partial resection was performed because of massive bleeding. Histological examination showed a GCT. After radiation therapy, the tumor recurred; the EEA and the anterior transpetrosal approaches were used to perform second and third operations, respectively. The MIB-1 index increased from 4.2% to 26.3%. Conclusions: GCTs are difficult to treat because of their location, vascularity, and the potential for malignant transformation.
AB - Background: Clival giant cell tumors (GCTs) are extremely rare with only eight cases reported to date, and malignant transformation is quite rare. Herein, we report a case of an uncontrolled clival GCT, which was transformed malignant, and review the literature. Case Description: A 25-year-old man experienced double vision for 1 month. Computed tomography and magnetic resonance imaging revealed a clival tumor. The endonasal endoscopic transsphenoidal approach (EEA) was used, and partial resection was performed because of massive bleeding. Histological examination showed a GCT. After radiation therapy, the tumor recurred; the EEA and the anterior transpetrosal approaches were used to perform second and third operations, respectively. The MIB-1 index increased from 4.2% to 26.3%. Conclusions: GCTs are difficult to treat because of their location, vascularity, and the potential for malignant transformation.
KW - Clivus
KW - giant cell tumor
KW - malignant transformation
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U2 - 10.4103/2152-7806.170459
DO - 10.4103/2152-7806.170459
M3 - Review article
AN - SCOPUS:84959287507
SN - 2152-7806
VL - 6
SP - S623-S627
JO - Surgical Neurology International
JF - Surgical Neurology International
ER -