Gingipains as candidate antigens for Porphyromonas gingivalis vaccine

Taneaki Nakagawa, Atsushi Saito, Yasuo Hosaka, Kazuyuki Ishihara

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobe, is involved in the pathogenesis of periodontal disease, and is found frequently in the subgingival flora in patients with periodontitis. This organism possesses a variety of virulence factors including lipopolysaccharide, capsular material, fimbriae and proteases (enzymes). Among the P. gingivalis antigens, enzymes such as Arginine-specific gingipains (RgpA, RgpB) and lysine-specific gingipain (Kgp) have been studied for their ability to induce biologically significant antibodies. This review summarizes recent information on the gingipains and their possible application in the development of an anti-P. gingivalis vaccine.

Original languageEnglish
Pages (from-to)158-162
Number of pages5
JournalKeio Journal of Medicine
Issue number3
Publication statusPublished - 2003 Sept


  • Gingipain
  • Periodontal disease
  • Porphyromonas gingivalis
  • Vaccine

ASJC Scopus subject areas

  • General Medicine


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