Global DNA hypomethylation coupled to cellular transformation and metastatic ability

Soichiro Funaki; Toshinobu Nakamura; Tsunetoshi Nakatani; Hiroki Umehara; Hiroyuki Nakashima; Meinoshin Okumura; Keisuke Oboki; Kenji Matsumoto; Hirohisa Saito; Toru Nakano

doi:10.1016/j.febslet.2015.11.020

Global DNA hypomethylation coupled to cellular transformation and metastatic ability

Soichiro Funaki
, Toshinobu Nakamura
, Tsunetoshi Nakatani
, Hiroki Umehara
, Hiroyuki Nakashima
, Meinoshin Okumura
, Keisuke Oboki
, Kenji Matsumoto
, Hirohisa Saito
, Toru Nakano

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Global DNA hypomethylation and DNA hypermethylation of promoter regions are frequently detected in human cancers. Although many studies have suggested a contribution to carcinogenesis, it is still unclear whether the aberrant DNA hypomethylation observed in tumors is a consequence or a cause of cancer. Here, we show that the enforced expression of Stella (also known as PGC7 and Dppa3) induced not only global DNA demethylation but also transformation of NIH3T3 cells. Furthermore, overexpression of Stella enhanced the metastatic ability of B16 melanoma cells, presumably through the induction of metastasis-related genes. These results provide new insights into the function of global DNA hypomethylation in carcinogenesis.

Original language	English
Pages (from-to)	4053-4060
Number of pages	8
Journal	FEBS Letters
Volume	589
Issue number	24
DOIs	https://doi.org/10.1016/j.febslet.2015.11.020
Publication status	Published - 2015 Dec 21
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA hypomethylation
Metastasis
Stella
Transformation

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/j.febslet.2015.11.020

Cite this

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title = "Global DNA hypomethylation coupled to cellular transformation and metastatic ability",

abstract = "Global DNA hypomethylation and DNA hypermethylation of promoter regions are frequently detected in human cancers. Although many studies have suggested a contribution to carcinogenesis, it is still unclear whether the aberrant DNA hypomethylation observed in tumors is a consequence or a cause of cancer. Here, we show that the enforced expression of Stella (also known as PGC7 and Dppa3) induced not only global DNA demethylation but also transformation of NIH3T3 cells. Furthermore, overexpression of Stella enhanced the metastatic ability of B16 melanoma cells, presumably through the induction of metastasis-related genes. These results provide new insights into the function of global DNA hypomethylation in carcinogenesis.",

keywords = "DNA hypomethylation, Metastasis, Stella, Transformation",

author = "Soichiro Funaki and Toshinobu Nakamura and Tsunetoshi Nakatani and Hiroki Umehara and Hiroyuki Nakashima and Meinoshin Okumura and Keisuke Oboki and Kenji Matsumoto and Hirohisa Saito and Toru Nakano",

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doi = "10.1016/j.febslet.2015.11.020",

language = "English",

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TY - JOUR

T1 - Global DNA hypomethylation coupled to cellular transformation and metastatic ability

AU - Funaki, Soichiro

AU - Nakamura, Toshinobu

AU - Nakatani, Tsunetoshi

AU - Umehara, Hiroki

AU - Nakashima, Hiroyuki

AU - Okumura, Meinoshin

AU - Oboki, Keisuke

AU - Matsumoto, Kenji

AU - Saito, Hirohisa

AU - Nakano, Toru

PY - 2015/12/21

Y1 - 2015/12/21

N2 - Global DNA hypomethylation and DNA hypermethylation of promoter regions are frequently detected in human cancers. Although many studies have suggested a contribution to carcinogenesis, it is still unclear whether the aberrant DNA hypomethylation observed in tumors is a consequence or a cause of cancer. Here, we show that the enforced expression of Stella (also known as PGC7 and Dppa3) induced not only global DNA demethylation but also transformation of NIH3T3 cells. Furthermore, overexpression of Stella enhanced the metastatic ability of B16 melanoma cells, presumably through the induction of metastasis-related genes. These results provide new insights into the function of global DNA hypomethylation in carcinogenesis.

AB - Global DNA hypomethylation and DNA hypermethylation of promoter regions are frequently detected in human cancers. Although many studies have suggested a contribution to carcinogenesis, it is still unclear whether the aberrant DNA hypomethylation observed in tumors is a consequence or a cause of cancer. Here, we show that the enforced expression of Stella (also known as PGC7 and Dppa3) induced not only global DNA demethylation but also transformation of NIH3T3 cells. Furthermore, overexpression of Stella enhanced the metastatic ability of B16 melanoma cells, presumably through the induction of metastasis-related genes. These results provide new insights into the function of global DNA hypomethylation in carcinogenesis.

KW - DNA hypomethylation

KW - Metastasis

KW - Stella

KW - Transformation

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UR - https://www.scopus.com/pages/publications/84959527126#tab=citedBy

U2 - 10.1016/j.febslet.2015.11.020

DO - 10.1016/j.febslet.2015.11.020

M3 - Article

C2 - 26608031

AN - SCOPUS:84959527126

SN - 0014-5793

VL - 589

SP - 4053

EP - 4060

JO - FEBS Letters

JF - FEBS Letters

IS - 24

ER -

Global DNA hypomethylation coupled to cellular transformation and metastatic ability

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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