Glomerulonephritis with microtubular deposits associated with cryoglobulinemia and chronic active hepatitis

Junichi Hirahashi, Shigeru Kuramochi, Konosuke Konishi, Akihiro Chikaraishi, Osamu Takase, Matsuhiko Hayashi, Takao Saruta

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A 65-year-old-woman presented with edema, ascites, proteinuria and abnormal liver function tests. A small amount of mixed cryoglobulin was detected in her serum. Liver biopsy revealed mild chronic active hepatitis, but tests for hepatotropic viral infection were negative. Electron microscopy of the renal biopsy revealed glomerular electrondense deposits that contained numerous tubular structures. Renal amyloidosis and light chain deposition disease were ruled out by appropriate histological techniques. The ultrastructural findings of renal biopsy suggested either cryoglobulinemic glomerulonephritis or immunotactoid glomerulopathy. Although the exact interrelationship among the peculiar glomerulopathy, cryoglobulinemia and chronic active hepatitis in the present case remains undetermined, this report enlarges the spectrum of glomerulopathy characterized by extracellular deposition of microtubules.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalPathology international
Issue number7
Publication statusPublished - 2002


  • Chronic active hepatitis
  • Cryoglobulinemic glomerulonephritis
  • Glomerular organized deposits

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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