TY - GEN
T1 - GLUCOSE-MONITORING JANUS HYDROGEL MICROBEADS WITH COMPENSATION FUNCIONS FOR SURROUNDING PH ENVIRONMENT
AU - Ando, Maru
AU - Tsuchiya, Mio
AU - Itai, Shun
AU - Heo, Yun Jung
AU - Onoe, Hiroaki
N1 - Funding Information:
The authors thank to Dr. Chiho Iwatani for managing this research project through Global Science Campus Program.
Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - This paper presents Janus microbeads for continuous fluorescent glucose monitoring with pH calibration. By using an UV- assisted centrifugal microfluidic device, the Janus hydrogel microbeads that consist of glucose sensor and pH sensor are easily fabricated. The microbead can calibrate the pH values of its surroundings and enables accurate measurements of glucose among various pH conditions. As a proof of concept, an accurate measurement of glucose concentration in the body-fluid-like solution using fluorescent intensities from glucose and pH sensor in microbeads was demonstrated. We believe that our fluorescent microbeads, with pH-calibration capacity, could be applied to fully implantable sensors for continuous glucose monitoring for diabetics.
AB - This paper presents Janus microbeads for continuous fluorescent glucose monitoring with pH calibration. By using an UV- assisted centrifugal microfluidic device, the Janus hydrogel microbeads that consist of glucose sensor and pH sensor are easily fabricated. The microbead can calibrate the pH values of its surroundings and enables accurate measurements of glucose among various pH conditions. As a proof of concept, an accurate measurement of glucose concentration in the body-fluid-like solution using fluorescent intensities from glucose and pH sensor in microbeads was demonstrated. We believe that our fluorescent microbeads, with pH-calibration capacity, could be applied to fully implantable sensors for continuous glucose monitoring for diabetics.
KW - Continuous glucose monitoring
KW - Glucose sensor
KW - Hydrogel
KW - Janus particle
KW - pH calibration
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M3 - Conference contribution
AN - SCOPUS:85136996084
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1129
EP - 1130
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -
