Glycoprotein 2 (GP2) grabbing the fimH+ bacteria into m cells for mucosal immunity

Hiroshi Ohno, Koji Hase

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


Membranous (M) cells are specialized epithelial antigentransporting cells scattered in the follicle-associated epithelium covering the gut lymphoid follicles such as Peyer's patches. Although the importance of M cells as a main portal for luminal antigens has long been recognized, molecular mechanisms for M-cell antigen uptake has remained largely elusive. We have recently found that glycoprotein 2 (GP2) is exclusively expressed on M cells among intestinal epithelial cells and serves as an uptake receptor for a subset of commensal and pathogenic bacteria. GP2 interacts with FimH, a major component of the type 1 pilus on the outer membrane of a subset of gram-negative enterobacilli such as E. coli and Salmonella enterica. Furthermore, GP2-FimH interaction is necessary for efficient uptake of FimH+ bacteria by M cells and subsequent bacteria- specific mucosal immune responses. Pancreatic GP2 may also be involved in innate immunity by 'opsonization' of FimH+ bacteria to facilitate their egestion in feces as well as translocation across the intestinal epithelium.

Original languageEnglish
Pages (from-to)407-410
Number of pages4
JournalGut microbes
Issue number6
Publication statusPublished - 2010
Externally publishedYes


  • Antigen uptake
  • Bacteria
  • Escherichia coli
  • FimH
  • IgA
  • M cells
  • Mucosal immunity
  • Salmonella typhimurium
  • Type I pili

ASJC Scopus subject areas

  • Microbiology (medical)
  • Gastroenterology
  • Infectious Diseases
  • Microbiology


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