Glycoprotein nanotube traps influenza virus

Shuta Yuge; Motofusa Akiyama; Makoto Ishii; Ho Namkoong; Kazuma Yagi; Yoko Nakai; Ryo Adachi; Teruyuki Komatsu

doi:10.1246/cl.160805

Glycoprotein nanotube traps influenza virus

Shuta Yuge, Motofusa Akiyama, Makoto Ishii, Ho Namkoong, Kazuma Yagi, Yoko Nakai, Ryo Adachi, Teruyuki Komatsu

Department of Internal Medicine (Pulmonary Medicine)

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We report the synthesis, structure, and influenza A virus trapping capability of protein nanotubes with an internal wall of fetuin glycoprotein. The nanotubes were fabricated via the alternating layer-by-layer assembly of human serum albumin (HSA), poly-L-arginine (PLA), and fetuin into a track-etched polycarbonate (PC) membrane (pore size, 800 nm), followed by dissolution of the PC template. In an aqueous medium, the (PLA/HSA)5 PLA/fetuin nanotubes captured influenza A virus PR8 (H1N1) efficiently, as revealed by ELISA measurements.

Original language	English
Pages (from-to)	95-97
Number of pages	3
Journal	Chemistry Letters
Volume	46
Issue number	1
DOIs	https://doi.org/10.1246/cl.160805
Publication status	Published - 2017

Keywords

Fetuin glycoprotein
Influenza virus
Layer-by-layer assembly

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.160805

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title = "Glycoprotein nanotube traps influenza virus",

abstract = "We report the synthesis, structure, and influenza A virus trapping capability of protein nanotubes with an internal wall of fetuin glycoprotein. The nanotubes were fabricated via the alternating layer-by-layer assembly of human serum albumin (HSA), poly-L-arginine (PLA), and fetuin into a track-etched polycarbonate (PC) membrane (pore size, 800 nm), followed by dissolution of the PC template. In an aqueous medium, the (PLA/HSA)5 PLA/fetuin nanotubes captured influenza A virus PR8 (H1N1) efficiently, as revealed by ELISA measurements.",

keywords = "Fetuin glycoprotein, Influenza virus, Layer-by-layer assembly",

author = "Shuta Yuge and Motofusa Akiyama and Makoto Ishii and Ho Namkoong and Kazuma Yagi and Yoko Nakai and Ryo Adachi and Teruyuki Komatsu",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research (B) (No. 15H03533) from JSPS (TK), a Grant-in-Aid for Exploratory Research (No. 26600030) from JSPS (TK), a Grant-in-Aid for Young Scientists (B) (No. 26870594) from JSPS (MA), and a Grant-in-Aid for Scientific Research (C) (No. 15K09580) (MI). The authors acknowledge Mr. Yuto Enomoto (Chuo University), for his skillful experiments related to fetuin nanotube preparation. Publisher Copyright: {\textcopyright} 2017 The Chemical Society of Japan.",

year = "2017",

doi = "10.1246/cl.160805",

language = "English",

volume = "46",

pages = "95--97",

journal = "Chemistry Letters",

issn = "0366-7022",

publisher = "Chemical Society of Japan",

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TY - JOUR

T1 - Glycoprotein nanotube traps influenza virus

AU - Yuge, Shuta

AU - Akiyama, Motofusa

AU - Ishii, Makoto

AU - Namkoong, Ho

AU - Yagi, Kazuma

AU - Nakai, Yoko

AU - Adachi, Ryo

AU - Komatsu, Teruyuki

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research (B) (No. 15H03533) from JSPS (TK), a Grant-in-Aid for Exploratory Research (No. 26600030) from JSPS (TK), a Grant-in-Aid for Young Scientists (B) (No. 26870594) from JSPS (MA), and a Grant-in-Aid for Scientific Research (C) (No. 15K09580) (MI). The authors acknowledge Mr. Yuto Enomoto (Chuo University), for his skillful experiments related to fetuin nanotube preparation. Publisher Copyright: © 2017 The Chemical Society of Japan.

PY - 2017

Y1 - 2017

N2 - We report the synthesis, structure, and influenza A virus trapping capability of protein nanotubes with an internal wall of fetuin glycoprotein. The nanotubes were fabricated via the alternating layer-by-layer assembly of human serum albumin (HSA), poly-L-arginine (PLA), and fetuin into a track-etched polycarbonate (PC) membrane (pore size, 800 nm), followed by dissolution of the PC template. In an aqueous medium, the (PLA/HSA)5 PLA/fetuin nanotubes captured influenza A virus PR8 (H1N1) efficiently, as revealed by ELISA measurements.

AB - We report the synthesis, structure, and influenza A virus trapping capability of protein nanotubes with an internal wall of fetuin glycoprotein. The nanotubes were fabricated via the alternating layer-by-layer assembly of human serum albumin (HSA), poly-L-arginine (PLA), and fetuin into a track-etched polycarbonate (PC) membrane (pore size, 800 nm), followed by dissolution of the PC template. In an aqueous medium, the (PLA/HSA)5 PLA/fetuin nanotubes captured influenza A virus PR8 (H1N1) efficiently, as revealed by ELISA measurements.

KW - Fetuin glycoprotein

KW - Influenza virus

KW - Layer-by-layer assembly

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SN - 0366-7022

VL - 46

SP - 95

EP - 97

JO - Chemistry Letters

JF - Chemistry Letters

IS - 1

ER -

Glycoprotein nanotube traps influenza virus

Abstract

Keywords

ASJC Scopus subject areas

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