Gold nanoparticle-mediated laser stimulation causes a complex stress signal in neuronal cells

Sonja Johannsmeier, Patrick Heeger, Mitsuhiro Terakawa, Stefan Kalies, Alexander Heisterkamp, Tammo Ripken, Dag Heinemann

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Gold nanoparticle mediated laser stimulation of neuronal cells allows for cell activation on a single-cell level. It could therefore be considered an alternative to classical electric neurostimulation. The physiological impact of this new approach has not been intensively studied so far. Here, we investigate the targeted cell's reaction to a laser stimulus based on its calcium response. A complex cellular reaction involving multiple sources has been revealed.

Original languageEnglish
Title of host publicationMedical Laser Applications and Laser-Tissue Interactions VIII
EditorsRonald Sroka, Lothar D. Lilge
PublisherSPIE
ISBN (Electronic)9781510612921
DOIs
Publication statusPublished - 2017
EventMedical Laser Applications and Laser-Tissue Interactions VIII 2017 - Munich, Germany
Duration: 2017 Jun 252017 Jun 29

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10417
ISSN (Print)1605-7422

Other

OtherMedical Laser Applications and Laser-Tissue Interactions VIII 2017
Country/TerritoryGermany
CityMunich
Period17/6/2517/6/29

Keywords

  • Gold nanoparticles
  • Laser-cell-interaction
  • Neuroimplants
  • Neurostimulation
  • Stress signaling

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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