Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy: A Case Report

Akira Toga; Kota Watanabe; Satoshi Suzuki; Satoshi Nori; Osahiko Tsuji; Narihito Nagoshi; Eijiro Okada; Mitsuru Yagi; Nobuyuki Fujita; Masaya Nakamura; Morio Matsumoto

doi:10.2106/JBJS.CC.20.00296

Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy: A Case Report

Akira Toga, Kota Watanabe, Satoshi Suzuki, Satoshi Nori, Osahiko Tsuji, Narihito Nagoshi, Eijiro Okada, Mitsuru Yagi, Nobuyuki Fujita, Masaya Nakamura, Morio Matsumoto

Department of Orthopaedics

Research output: Contribution to journal › Article › peer-review

Abstract

CASE: Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery. CONCLUSION: This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.

Original language	English
Journal	JBJS case connector
Volume	11
Issue number	1
DOIs	https://doi.org/10.2106/JBJS.CC.20.00296
Publication status	Published - 2021 Mar 3

ASJC Scopus subject areas

Medicine(all)

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10.2106/JBJS.CC.20.00296

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title = "Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy: A Case Report",

abstract = "CASE: Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery. CONCLUSION: This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.",

author = "Akira Toga and Kota Watanabe and Satoshi Suzuki and Satoshi Nori and Osahiko Tsuji and Narihito Nagoshi and Eijiro Okada and Mitsuru Yagi and Nobuyuki Fujita and Masaya Nakamura and Morio Matsumoto",

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doi = "10.2106/JBJS.CC.20.00296",

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T1 - Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy

T2 - A Case Report

AU - Toga, Akira

AU - Watanabe, Kota

AU - Suzuki, Satoshi

AU - Nori, Satoshi

AU - Tsuji, Osahiko

AU - Nagoshi, Narihito

AU - Okada, Eijiro

AU - Yagi, Mitsuru

AU - Fujita, Nobuyuki

AU - Nakamura, Masaya

AU - Matsumoto, Morio

PY - 2021/3/3

Y1 - 2021/3/3

N2 - CASE: Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery. CONCLUSION: This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.

AB - CASE: Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery. CONCLUSION: This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.

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Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy: A Case Report

Abstract

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