Gradual vs. wait-and-gradual discontinuation in antipsychotic switching: A meta-analysis

Hiroyoshi Takeuchi; Sadhana Thiyanavadivel; Ofer Agid; Gary Remington

doi:10.1016/j.schres.2017.02.011

Gradual vs. wait-and-gradual discontinuation in antipsychotic switching: A meta-analysis

Hiroyoshi Takeuchi, Sadhana Thiyanavadivel, Ofer Agid, Gary Remington

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

To address whether wait discontinuation (i.e., introducing the new antipsychotic while maintaining the first for a period before initiating its discontinuation) is superior to non-wait discontinuation (i.e., initiating the first antipsychotic's discontinuation when introducing the new antipsychotic) in antipsychotic switching, we conducted a meta-analysis of randomized controlled trials comparing gradual vs. wait-and-gradual antipsychotic discontinuation in patients with schizophrenia. The meta-analysis of 5 studies (n = 410) demonstrated no significant differences in any clinical outcomes, including study discontinuation, psychopathology, extrapyramidal symptoms, and treatment-emergent adverse events, between the two groups. These findings indicate either strategy can be used in clinical practice.

Original language	English
Pages (from-to)	4-8
Number of pages	5
Journal	Schizophrenia Research
Volume	189
DOIs	https://doi.org/10.1016/j.schres.2017.02.011
Publication status	Published - 2017 Nov

Keywords

Antipsychotics
Discontinuation
Schizophrenia
Switching strategy

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2017.02.011

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abstract = "To address whether wait discontinuation (i.e., introducing the new antipsychotic while maintaining the first for a period before initiating its discontinuation) is superior to non-wait discontinuation (i.e., initiating the first antipsychotic's discontinuation when introducing the new antipsychotic) in antipsychotic switching, we conducted a meta-analysis of randomized controlled trials comparing gradual vs. wait-and-gradual antipsychotic discontinuation in patients with schizophrenia. The meta-analysis of 5 studies (n = 410) demonstrated no significant differences in any clinical outcomes, including study discontinuation, psychopathology, extrapyramidal symptoms, and treatment-emergent adverse events, between the two groups. These findings indicate either strategy can be used in clinical practice.",

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AU - Thiyanavadivel, Sadhana

AU - Agid, Ofer

AU - Remington, Gary

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AB - To address whether wait discontinuation (i.e., introducing the new antipsychotic while maintaining the first for a period before initiating its discontinuation) is superior to non-wait discontinuation (i.e., initiating the first antipsychotic's discontinuation when introducing the new antipsychotic) in antipsychotic switching, we conducted a meta-analysis of randomized controlled trials comparing gradual vs. wait-and-gradual antipsychotic discontinuation in patients with schizophrenia. The meta-analysis of 5 studies (n = 410) demonstrated no significant differences in any clinical outcomes, including study discontinuation, psychopathology, extrapyramidal symptoms, and treatment-emergent adverse events, between the two groups. These findings indicate either strategy can be used in clinical practice.

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Gradual vs. wait-and-gradual discontinuation in antipsychotic switching: A meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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