Graft Failure after Uterus Transplantation in 16 Recipients: A Review

Iori Kisu, Risa Matsuda, Tetsuro Shiraishi, Ryoma Hayashi, Yusuke Matoba, Masato Tamate, Kouji Banno

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Uterus transplantation (UTx) is now an alternative to surrogacy and adoption for women with uterine factor infertility to have children; however, there are still unresolved clinical and technical issues. One of these is that the graft failure rate after transplantation is somewhat higher than that of other life-saving organ transplants, which is a critical concern. Herein, we summarize the details of 16 graft failures after UTx with living or deceased donors using the published literature in order to learn from these negative outcomes. To date, the main causes of graft failure are vascular factors (arterial and/or venous thrombosis, atherosclerosis, and poor perfusion). Many recipients with thrombosis develop graft failure within one month of surgery. Therefore, it is necessary to devise a safe and stable surgical technique with higher success rates for further development in the UTx field.

Original languageEnglish
Article number2032
JournalJournal of Clinical Medicine
Volume12
Issue number5
DOIs
Publication statusPublished - 2023 Mar

Keywords

  • graft failure
  • hysterectomy
  • thrombosis
  • uterine factor infertility
  • uterine infection
  • uterus transplantation

ASJC Scopus subject areas

  • General Medicine

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