TY - JOUR
T1 - Granular lymphocytic leukemia derived from γδ T-cell expressing cytotoxic molecules
AU - Saito, Takeshi
AU - Togitani, Kazuto
AU - Murakami, Jun
AU - Watanabe, Takashi
AU - Tanosaki, Ryuji
AU - Kobayashi, Yukio
AU - Matsuno, Yoshihiro
AU - Tobinai, Kensei
N1 - Funding Information:
This study was supported by the Grants-in-Aid for Cancer Research (11-8) from the Ministry of Health and Welfare of Japan. T. Saito provided the concept, design, collected the data and analyzed it, drafted the article and gave final approval. K. Togitani and J. Murakami provided study materials, gave critical reviews and final approval for the paper. T. Watanabe, R. Tanosaki and Y. Kobayashi assisted with the interpretation of data, provided critical review and gave final approval. Y. Matsuno collected and analyzed data, provided study material, gave critical input to the revision and gave final approval. K. Tobinai contributed to all aspects of the study as well as providing necessary funding.
PY - 2001
Y1 - 2001
N2 - We here present an extremely rare case of granular lymphocytic leukemia derived from γδ T-cell (γδ T-GLL). The blood picture at diagnosis was as follows; white cell count 25.7×109/l containing 94% atypical lymphocytes with cytoplasmic granules, hemoglobin 11.8 g/dl and platelet count 124×109/l. The atypical lymphocytes were positive for CD2, CD3, CD5, CD7, CD56 and TCR γδ, but negative for CD4, CD8, CD57, TCR αβ and B-cell antigens. The cytotoxic molecules, T-cell intracellular antigen-1 (TIA-1) and granzyme B, were positive by immunocytochemical analysis. Southern blot analysis showed rearrangement of T-cell receptor Jγ and Cβ genes but germline configuration of the JH gene. Neither serum antibody against human T-cell leukemia virus type-I (HTLV-I) nor the integration of HTLV-I proviral DNA was detected. CT scan showed splenomegaly but no lymph node enlargement. A diagnosis of γδ T-GLL was made, and she has been followed up without any therapies for more than 4 years.
AB - We here present an extremely rare case of granular lymphocytic leukemia derived from γδ T-cell (γδ T-GLL). The blood picture at diagnosis was as follows; white cell count 25.7×109/l containing 94% atypical lymphocytes with cytoplasmic granules, hemoglobin 11.8 g/dl and platelet count 124×109/l. The atypical lymphocytes were positive for CD2, CD3, CD5, CD7, CD56 and TCR γδ, but negative for CD4, CD8, CD57, TCR αβ and B-cell antigens. The cytotoxic molecules, T-cell intracellular antigen-1 (TIA-1) and granzyme B, were positive by immunocytochemical analysis. Southern blot analysis showed rearrangement of T-cell receptor Jγ and Cβ genes but germline configuration of the JH gene. Neither serum antibody against human T-cell leukemia virus type-I (HTLV-I) nor the integration of HTLV-I proviral DNA was detected. CT scan showed splenomegaly but no lymph node enlargement. A diagnosis of γδ T-GLL was made, and she has been followed up without any therapies for more than 4 years.
KW - Cytotoxic molecule
KW - Granular lymphocytic leukemia
KW - T-cell receptor
KW - γδ T-GLL
KW - γδ T-cell
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U2 - 10.1016/S0145-2126(00)00115-6
DO - 10.1016/S0145-2126(00)00115-6
M3 - Article
C2 - 11226523
AN - SCOPUS:0035131892
SN - 0145-2126
VL - 25
SP - 259
EP - 261
JO - Leukemia Research
JF - Leukemia Research
IS - 3
ER -
