Guideline for the diagnosis and treatment of scabies in Japan (second edition)

Norihisa Ishii, Akihiko Asahina, Masayuki Amagai, Masafumi Iijima, Osamu Ishikawa, Hidekazu Imamura, Mariko Ooe, Noriko Ohtaki, Yasuhiko Kato, Nobuo Kanazawa, Ryoichi Kamide, Tamotsu Kanzaki, Akira Konohana, Masayo Komoda, Natsuko Sugiyama, Mari Sekine, Shinichiro Takezaki, Masaru Tanaka, Nobuko Tamura, Yuzuru NagaokaHiroko Nanko, Masayuki Hayashi, Kuniko Makigami, Tomoko Matsuda, Junko Yoshizumi, Yasuo Wada

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)


The guideline has been prepared by the Japanese Dermatological Association to ensure proper diagnosis and treatment of scabies, as oral therapy became available on August 2006 under health insurance and its clinical use was expected to increase. For making a proper diagnosis, the following three points should be taken into consideration: (i) clinical symptoms; (ii) detection of the mite (Sarcoptes scabiei); and (iii) epidemiological symptoms. The diagnosis is confirmed if the mites or eggs are identified by microscopy or dermoscopy and so forth. Topical sulfur preparations, with only limited usefulness, are the only available topical drugs approved by health insurance coverage for treating scabies. Currently, crotamiton, benzyl benzoate and γ-benzene hexachloride are also used clinically. It is important to apply these to the whole-body, including hands, fingers and genitals. The dose for ivermectin is a single administration p.o. of approximately 200 μg/kg bodyweight with water before a meal. Administration of a second dose is considered, if new specific lesions develop or the mites are detected. For treating crusted scabies, concomitant administration of oral ivermectin and the topical preparation is necessary. Some safe and useful topical drug preparations are needed to be approved by health insurance.

Original languageEnglish
Pages (from-to)378-393
Number of pages16
JournalJournal of Dermatology
Issue number6
Publication statusPublished - 2008 Jun


  • Crotamiton
  • Crusted scabies
  • Dermoscopy
  • Guideline
  • Ivermectin
  • Scabies

ASJC Scopus subject areas

  • Dermatology


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