Gut microbiota prevents sugar alcohol-induced diarrhea

Kouya Hattori, Masahiro Akiyama, Natsumi Seki, Kyosuke Yakabe, Koji Hase, Yun Gi Kim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


While poorly-absorbed sugar alcohols such as sorbitol are widely used as sweeteners, they may induce diarrhea in some individuals. However, the factors which determine an individual’s susceptibility to sugar alcohol-induced diarrhea remain unknown. Here, we show that specific gut bacteria are involved in the suppression of sorbitol-induced diarrhea. Based on 16S rDNA analysis, the abundance of Enterobacteriaceae bacteria increased in response to sorbitol consumption. We found that Escherichia coli of the family Enterobacteriaceae degraded sorbitol and suppressed sorbitol-induced diarrhea. Finally, we showed that the metabolism of sorbitol by the E. coli sugar phosphotransferase system helped suppress sorbitol-induced diarrhea. Therefore, gut microbiota prevented sugar alcohol-induced diarrhea by degrading sorbitol in the gut. The identification of the gut bacteria which respond to and degrade sugar alcohols in the intestine has implications for microbiome science, processed food science, and public health.

Original languageEnglish
Article number2029
Issue number6
Publication statusPublished - 2021 Jun


  • Diarrhea
  • Gut microbiota
  • Sugar alcohol

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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