H1 genotype of measles virus was detected in outbreaks in Japan after 2000

Jianhui Zhou; Motoko Fujino; Youko Inou; Atsushi Kumada; Yasuko Aoki; Satoshi Iwata; Tetsuo Nakayama

doi:10.1002/jmv.10443

H1 genotype of measles virus was detected in outbreaks in Japan after 2000

Jianhui Zhou, Motoko Fujino, Youko Inou, Atsushi Kumada, Yasuko Aoki, Satoshi Iwata, Tetsuo Nakayama

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

We investigated the molecular epidemiology and biological characteristics of wild measles viruses isolated since 1984 in Japan. The circulating measles virus was of genotype C1 before 1985, D3 from 1987 to 1990, and D5 from 1990 to 1997. It was replaced by the same cluster of Chicago-type D3 strain from 1997 to 1999. In 2000, D5 recirculated with sporadic cases caused by genotype H1. The H1 genotype became dominant in 2001 with a minor distribution of D5. No significant difference was observed in neutralizing titers against C1, D3, D5, and H1 when we used sera having high neutralizing titers. However, some D3 and H1 strains were not completely neutralized with low levels of neutralizing antibody, and maintaining high levels of measles antibodies would be required for the control measles outbreaks.

Original language	English
Pages (from-to)	642-648
Number of pages	7
Journal	Journal of Medical Virology
Volume	70
Issue number	4
DOIs	https://doi.org/10.1002/jmv.10443
Publication status	Published - 2003 Aug 1
Externally published	Yes

Keywords

Antigenicity
Measles virus
Molecular epidemiology
Neutralizing antibody

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.10443

Cite this

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title = "H1 genotype of measles virus was detected in outbreaks in Japan after 2000",

abstract = "We investigated the molecular epidemiology and biological characteristics of wild measles viruses isolated since 1984 in Japan. The circulating measles virus was of genotype C1 before 1985, D3 from 1987 to 1990, and D5 from 1990 to 1997. It was replaced by the same cluster of Chicago-type D3 strain from 1997 to 1999. In 2000, D5 recirculated with sporadic cases caused by genotype H1. The H1 genotype became dominant in 2001 with a minor distribution of D5. No significant difference was observed in neutralizing titers against C1, D3, D5, and H1 when we used sera having high neutralizing titers. However, some D3 and H1 strains were not completely neutralized with low levels of neutralizing antibody, and maintaining high levels of measles antibodies would be required for the control measles outbreaks.",

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author = "Jianhui Zhou and Motoko Fujino and Youko Inou and Atsushi Kumada and Yasuko Aoki and Satoshi Iwata and Tetsuo Nakayama",

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AU - Zhou, Jianhui

AU - Fujino, Motoko

AU - Inou, Youko

AU - Kumada, Atsushi

AU - Aoki, Yasuko

AU - Iwata, Satoshi

AU - Nakayama, Tetsuo

PY - 2003/8/1

Y1 - 2003/8/1

N2 - We investigated the molecular epidemiology and biological characteristics of wild measles viruses isolated since 1984 in Japan. The circulating measles virus was of genotype C1 before 1985, D3 from 1987 to 1990, and D5 from 1990 to 1997. It was replaced by the same cluster of Chicago-type D3 strain from 1997 to 1999. In 2000, D5 recirculated with sporadic cases caused by genotype H1. The H1 genotype became dominant in 2001 with a minor distribution of D5. No significant difference was observed in neutralizing titers against C1, D3, D5, and H1 when we used sera having high neutralizing titers. However, some D3 and H1 strains were not completely neutralized with low levels of neutralizing antibody, and maintaining high levels of measles antibodies would be required for the control measles outbreaks.

AB - We investigated the molecular epidemiology and biological characteristics of wild measles viruses isolated since 1984 in Japan. The circulating measles virus was of genotype C1 before 1985, D3 from 1987 to 1990, and D5 from 1990 to 1997. It was replaced by the same cluster of Chicago-type D3 strain from 1997 to 1999. In 2000, D5 recirculated with sporadic cases caused by genotype H1. The H1 genotype became dominant in 2001 with a minor distribution of D5. No significant difference was observed in neutralizing titers against C1, D3, D5, and H1 when we used sera having high neutralizing titers. However, some D3 and H1 strains were not completely neutralized with low levels of neutralizing antibody, and maintaining high levels of measles antibodies would be required for the control measles outbreaks.

KW - Antigenicity

KW - Measles virus

KW - Molecular epidemiology

KW - Neutralizing antibody

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H1 genotype of measles virus was detected in outbreaks in Japan after 2000

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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