Headache in consideration of gender

Toshihiko Shimizu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Among headaches sufferers in Japan, especially the number of migraine sufferers in Japan is estimated about 8,400 thousands, and the ratio of men and women is said to be about 1 to 4. The pathophysiology of migraines has been commonly explained by the trigeminovascular theory, and recent studies have suggested that the cause of migraines stems from cortical hypersensitivity. As to prophylactic treatment of migraine, anti-epileptic drugs such as valproic acid for cephalic hypersensitivity symptoms may be effective for reducing intensity and frequency of attacks and first line abortive medicine are triptans, which are widely prescribed. Considering from migraine treatment methods from childhood to elder women, to decreasing hypersensitivity of the brain in each life stage will lead falling into medication over used headache and also suppressing development of dizziness, tinnitus, or cephalic ringing in future, and shows that anti-epileptics are effective for treating this condition.

Original languageEnglish
Pages (from-to)656-660
Number of pages5
JournalNihon rinsho. Japanese journal of clinical medicine
Issue number4
Publication statusPublished - 2015 Apr 1

ASJC Scopus subject areas

  • Medicine(all)


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