TY - JOUR
T1 - Health-related quality of life in peripheral blood stem cell donors and bone marrow donors
T2 - a prospective study in Japan
AU - Fujimoto, Ayumi
AU - Suzuki, Ritsuro
AU - Orihara, Katsumi
AU - Iida, Minako
AU - Yamashita, Takuya
AU - Nagafuji, Koji
AU - Kanamori, Heiwa
AU - Kodera, Yoshihisa
AU - Miyamura, Koichi
AU - Okamoto, Shinichiro
AU - Hino, Masayuki
N1 - Funding Information:
We thank all the physicians who helped to gather data from donors and data managers at the JMDP. This work was supported in part by the Practical Research Project for Allergic Disease and Immunology (Research Technology of Medical Transplantation) from the Ministry of Health, Labor and Welfare of Japan.
Publisher Copyright:
© 2020, Japanese Society of Hematology.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Understanding of the impact of stem cell donation on donors’ health-related quality of life (HRQOL) remains limited. A prospective observational study of eligible unrelated donors enrolled in the Japan Marrow Donor Program was conducted to compare HRQOL and adverse events (AEs) between peripheral blood stem cell (PBSC) and bone marrow (BM) donors. In total, 107 PBSC donors and 108 BM donors were enrolled. HRQOL scores for physical status were significantly lower in BM donors 1 week post-harvest (P < 0.001), but there were no significant differences between the two groups at baseline or 3 months post-harvest. PBSC donors were more likely to experience AEs before harvest (P < 0.001). However, at harvest, moderate-to-severe AEs were more common in BM donors (P = 0.001). After harvest, all grades of AEs were significantly higher in BM donors (P < 0.001). Among BM donors, a lower total physical score at baseline [odds ratio (OR) 1.21], female sex [OR 2.71], and young donors (OR 3.08) were risk factors for moderate-to-severe AEs at harvest, while among PBSC donors, only female sex (OR 4.86) was a risk factor. Our findings show better HRQOL during PBSC donation. These data help support decision-making by potential donors.
AB - Understanding of the impact of stem cell donation on donors’ health-related quality of life (HRQOL) remains limited. A prospective observational study of eligible unrelated donors enrolled in the Japan Marrow Donor Program was conducted to compare HRQOL and adverse events (AEs) between peripheral blood stem cell (PBSC) and bone marrow (BM) donors. In total, 107 PBSC donors and 108 BM donors were enrolled. HRQOL scores for physical status were significantly lower in BM donors 1 week post-harvest (P < 0.001), but there were no significant differences between the two groups at baseline or 3 months post-harvest. PBSC donors were more likely to experience AEs before harvest (P < 0.001). However, at harvest, moderate-to-severe AEs were more common in BM donors (P = 0.001). After harvest, all grades of AEs were significantly higher in BM donors (P < 0.001). Among BM donors, a lower total physical score at baseline [odds ratio (OR) 1.21], female sex [OR 2.71], and young donors (OR 3.08) were risk factors for moderate-to-severe AEs at harvest, while among PBSC donors, only female sex (OR 4.86) was a risk factor. Our findings show better HRQOL during PBSC donation. These data help support decision-making by potential donors.
KW - Adverse events
KW - Health-related quality of life
KW - Risk factors
KW - Stem cell donors
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U2 - 10.1007/s12185-020-02852-7
DO - 10.1007/s12185-020-02852-7
M3 - Article
AN - SCOPUS:85081718296
SN - 0925-5710
VL - 111
SP - 840
EP - 850
JO - International journal of hematology
JF - International journal of hematology
IS - 6
ER -