Heart regeneration using reprogramming technology

Masaki Ieda

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


Loss of terminally differentiated cardiomyocytes due to heart disease is irreversible and current therapeutic regimes are limited. Cell therapy using stem cell-derived cardiomyocytes is an attractive option to repair injured hearts. The discovery of direct reprogramming of broblasts into induced pluripotent stem cells (iPSCs) and successful differentiation of iPSCs into cardiomyocytes provided a revolutionary paradigm in heart regenerative research. During the past decades, signicant advances in stem cell culture, differentiation and purication protocols, as well as in cell transplantation methodologies, have been achieved. On the other hand, recent studies demonstrated that a somatic cell could be converted into an alternative differentiated cell type without rst becoming a stem cell by overexpression of lineage-specic factors. We found that functional cardiomyocytes can be directly induced from broblasts by a combination of three cardiac transcription factors, Gata4, Mef2c and Tbx5, in vitro and in vivo. I will review the perspectives of heart regeneration using reprogramming technology.

Original languageEnglish
Pages (from-to)118-128
Number of pages11
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Issue number3
Publication statusPublished - 2013
Externally publishedYes


  • Heart
  • Heart regeneration
  • IPS cell
  • Induced cardiomyocyte
  • Reprogramming

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Physics and Astronomy


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