TY - JOUR
T1 - Hematopoietic stem cells and their niche
AU - Suda, Toshio
AU - Arai, Fumio
AU - Hirao, Atsushi
N1 - Funding Information:
This work was supported by a grant-in-aid from Specially Promoted Research of the Ministry of Education, Science, Sports and Culture, Japan.
PY - 2005/8
Y1 - 2005/8
N2 - Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules. In this review, the characteristics of HSCs in the niche are discussed. The understanding of the relationship between normal and cancer stem cells and their niches should lead to the development of new strategies directed toward regeneration medicine and cancer therapeutics.
AB - Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules. In this review, the characteristics of HSCs in the niche are discussed. The understanding of the relationship between normal and cancer stem cells and their niches should lead to the development of new strategies directed toward regeneration medicine and cancer therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=22444447491&partnerID=8YFLogxK
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U2 - 10.1016/j.it.2005.06.006
DO - 10.1016/j.it.2005.06.006
M3 - Review article
C2 - 15979407
AN - SCOPUS:22444447491
SN - 1471-4906
VL - 26
SP - 426
EP - 433
JO - Trends in Immunology
JF - Trends in Immunology
IS - 8
ER -
