Hemopoietic stem cells in nude mice transplanted with colony-stimulating factor-producing tumors

H. Mizoguchi, T. Suda, Y. Miura, K. Kubota, F. Takaku

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16 Citations (Scopus)


When pieces of a human pulmonary carcinoma which was producing colony-stimulating factor (CSF) were transplanted into nude mice a marked granulocytosis of 10 6/mm 3 was observed in the nude mice 4 weeks after the transplantation. In order to elucidate the control mechanism of hemopoiesis, we studied the kinetics of the hemopoietic stem cells of these mice. The number of GM-CFC, CFU(E), Meg-CFC and CFU(S) in the whole body increased to 6 times, 8 times, 6 times and 36 times as much respectively as those of the control mice. The increase in the number of these progenitors occurred mainly in the spleen. The sera of these mice contained only CSF. The cycling fraction of GM-CFC and CFU(S) determined by thymidine suicide technique was increased. From these findings, it could be considered that CSF produced in these mice acted directly or indirectly on CFU(S) including their differentiation into committed stem cells.

Original languageEnglish
Pages (from-to)874-880
Number of pages7
JournalExperimental Hematology
Issue number10
Publication statusPublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research


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