TY - JOUR
T1 - Hepatic Tissue Oxygen Tension and Regional Hepatic Blood Volume in Alcoholic Fatty Liver
AU - Kamada, Takenobu
AU - Sato, Nobuhiro
AU - Meren, Haruya
AU - Inoue, Atsuo
AU - Kasahara, Akinori
AU - Yoshihara, Harumasa
AU - Sasaki, Yutaka
AU - Hayashi, Norio
AU - Fusamoto, Hideyuki
AU - Abe, Hiroshi
AU - Kishida, Yutaka
AU - Takagi, Toshikazu
AU - Kato, Shinzou
AU - Ishii, Hiromasa
AU - Tsuchiya, Masaharu
PY - 1984/1
Y1 - 1984/1
N2 - In vivo hepatic tissue oxygen tension (hepatic tissue PO2) and regional hepatic blood volume were investigated by thin needle oxygen electrode and organ-reflectance spectrophotometry in chronically ethanol treated and pair-fed control rats. The hepatic tissue PO2 in chronically ethanol treated rats (7.1 ± 2.9 mmHg) was significantly lower than that in control rats (16.6 ± 8.8 mmHg). In chronically ethanol treated rats, the regional hepatic blood volume was signifcantly lower as compared with that in control rats. After acute oral ethanol administration (1 g/kg BW), the hepatic tissue PO2 in control rats increased about twofolds over basal level, while in chronically ethanol treated rats, the hepatic tissue PO2 decreased transiently, followed by a gradual increase. The increase of regional hepatic blood volume in chronically ethanol treated rats (4.9%) was lower than that in control rats (8.4%). It is concluded that in rats the liver was hypoxic even in the stage of fatty liver, probably due to the decreased hepatic blood supply.
AB - In vivo hepatic tissue oxygen tension (hepatic tissue PO2) and regional hepatic blood volume were investigated by thin needle oxygen electrode and organ-reflectance spectrophotometry in chronically ethanol treated and pair-fed control rats. The hepatic tissue PO2 in chronically ethanol treated rats (7.1 ± 2.9 mmHg) was significantly lower than that in control rats (16.6 ± 8.8 mmHg). In chronically ethanol treated rats, the regional hepatic blood volume was signifcantly lower as compared with that in control rats. After acute oral ethanol administration (1 g/kg BW), the hepatic tissue PO2 in control rats increased about twofolds over basal level, while in chronically ethanol treated rats, the hepatic tissue PO2 decreased transiently, followed by a gradual increase. The increase of regional hepatic blood volume in chronically ethanol treated rats (4.9%) was lower than that in control rats (8.4%). It is concluded that in rats the liver was hypoxic even in the stage of fatty liver, probably due to the decreased hepatic blood supply.
UR - http://www.scopus.com/inward/record.url?scp=0021274852&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021274852&partnerID=8YFLogxK
U2 - 10.11405/nisshoshi1964.81.1019
DO - 10.11405/nisshoshi1964.81.1019
M3 - Article
C2 - 6748312
AN - SCOPUS:0021274852
SN - 0446-6586
VL - 81
SP - 1019
EP - 1023
JO - Nippon Shokakibyo Gakkai Zasshi
JF - Nippon Shokakibyo Gakkai Zasshi
IS - 4
ER -