Hepatoprotective activity of phenylethanoids from Cistanche deserticola

Quanbo Xiong; Koji Hase; Yasuhiro Tezuka; Tadato Tani; Tsuneo Namba; Shigetoshi Kadota

doi:10.1055/s-2006-957387

Hepatoprotective activity of phenylethanoids from Cistanche deserticola

Quanbo Xiong, Koji Hase, Yasuhiro Tezuka, Tadato Tani, Tsuneo Namba, Shigetoshi Kadota

Research output: Contribution to journal › Article › peer-review

140 Citations (Scopus)

Abstract

Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl₄-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl₄ or D-galactosamine (D- GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl₄ in vivo.

Original language	English
Pages (from-to)	120-125
Number of pages	6
Journal	Planta Medica
Volume	64
Issue number	2
DOIs	https://doi.org/10.1055/s-2006-957387
Publication status	Published - 1998
Externally published	Yes

Keywords

Carbon tetrachloride
Cistanche deserticola
D-galactosamine
Hepatoprotective activity
Orobanchaceae
Phenylethanoids

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1055/s-2006-957387

Cite this

@article{eba8cde874334714a62c9bac5513eac3,

title = "Hepatoprotective activity of phenylethanoids from Cistanche deserticola",

abstract = "Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D- GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.",

keywords = "Carbon tetrachloride, Cistanche deserticola, D-galactosamine, Hepatoprotective activity, Orobanchaceae, Phenylethanoids",

author = "Quanbo Xiong and Koji Hase and Yasuhiro Tezuka and Tadato Tani and Tsuneo Namba and Shigetoshi Kadota",

year = "1998",

doi = "10.1055/s-2006-957387",

language = "English",

volume = "64",

pages = "120--125",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "2",

}

TY - JOUR

T1 - Hepatoprotective activity of phenylethanoids from Cistanche deserticola

AU - Xiong, Quanbo

AU - Hase, Koji

AU - Tezuka, Yasuhiro

AU - Tani, Tadato

AU - Namba, Tsuneo

AU - Kadota, Shigetoshi

PY - 1998

Y1 - 1998

N2 - Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D- GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.

AB - Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D- GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.

KW - Carbon tetrachloride

KW - Cistanche deserticola

KW - D-galactosamine

KW - Hepatoprotective activity

KW - Orobanchaceae

KW - Phenylethanoids

UR - http://www.scopus.com/inward/record.url?scp=0031976872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031976872&partnerID=8YFLogxK

U2 - 10.1055/s-2006-957387

DO - 10.1055/s-2006-957387

M3 - Article

C2 - 9525102

AN - SCOPUS:0031976872

SN - 0032-0943

VL - 64

SP - 120

EP - 125

JO - Planta Medica

JF - Planta Medica

IS - 2

ER -

Hepatoprotective activity of phenylethanoids from Cistanche deserticola

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this