Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea

Koji Hase; Shigetoshi Kadota; Purusotam Basnet; Tsuneo Namba; Tooru Takahashi

doi:10.1002/(SICI)1099-1573(199608)10:5<387::AID-PTR856>3.0.CO;2-V

Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea

Koji Hase, Shigetoshi Kadota, Purusotam Basnet, Tsuneo Namba, Tooru Takahashi

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The hepatoprotective effects of water extracts from twelve crude drugs were investigated. Among them, the water extracts of Cassia obtusifolia, Celosia argentea, Cucurbita moschata and Curcuma aeruginosa showed a significant protective effect on carbon tetrachloride induced liver injury in rats and D-galactosamine (D-GalN)/lipopolysaccharide (LPS) induced liver injury in mice. The water extract of C. argentea was found to be the most effective. The hepatoprotective activity guided fractionation of this extract led to the isolation of an active constituent. This component was named as celosian, and was found to be an acidic heteroglycan (molecular weight: 1.9 x 10⁵) containing 4% of proteins.

Original language	English
Pages (from-to)	387-392
Number of pages	6
Journal	Phytotherapy Research
Volume	10
Issue number	5
DOIs	https://doi.org/10.1002/(SICI)1099-1573(199608)10:5<387::AID-PTR856>3.0.CO;2-V
Publication status	Published - 1996 Aug 15
Externally published	Yes

Keywords

Carbon tetrachloride
Celosia argentea
Celosian
D-galactosamine
Hepatoprotective effect
Lipopolysaccharide

ASJC Scopus subject areas

Pharmacology

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10.1002/(SICI)1099-1573(199608)10:5<387::AID-PTR856>3.0.CO;2-V

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title = "Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea",

abstract = "The hepatoprotective effects of water extracts from twelve crude drugs were investigated. Among them, the water extracts of Cassia obtusifolia, Celosia argentea, Cucurbita moschata and Curcuma aeruginosa showed a significant protective effect on carbon tetrachloride induced liver injury in rats and D-galactosamine (D-GalN)/lipopolysaccharide (LPS) induced liver injury in mice. The water extract of C. argentea was found to be the most effective. The hepatoprotective activity guided fractionation of this extract led to the isolation of an active constituent. This component was named as celosian, and was found to be an acidic heteroglycan (molecular weight: 1.9 x 105) containing 4% of proteins.",

keywords = "Carbon tetrachloride, Celosia argentea, Celosian, D-galactosamine, Hepatoprotective effect, Lipopolysaccharide",

author = "Koji Hase and Shigetoshi Kadota and Purusotam Basnet and Tsuneo Namba and Tooru Takahashi",

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AU - Hase, Koji

AU - Kadota, Shigetoshi

AU - Basnet, Purusotam

AU - Namba, Tsuneo

AU - Takahashi, Tooru

PY - 1996/8/15

Y1 - 1996/8/15

N2 - The hepatoprotective effects of water extracts from twelve crude drugs were investigated. Among them, the water extracts of Cassia obtusifolia, Celosia argentea, Cucurbita moschata and Curcuma aeruginosa showed a significant protective effect on carbon tetrachloride induced liver injury in rats and D-galactosamine (D-GalN)/lipopolysaccharide (LPS) induced liver injury in mice. The water extract of C. argentea was found to be the most effective. The hepatoprotective activity guided fractionation of this extract led to the isolation of an active constituent. This component was named as celosian, and was found to be an acidic heteroglycan (molecular weight: 1.9 x 105) containing 4% of proteins.

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KW - Carbon tetrachloride

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KW - Celosian

KW - D-galactosamine

KW - Hepatoprotective effect

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Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea

Abstract

Keywords

ASJC Scopus subject areas

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