TY - JOUR
T1 - High-dose antidepressants affect near-infrared spectroscopy signals
T2 - A retrospective study
AU - Takamiya, Akihiro
AU - Hirano, Jinichi
AU - Ebuchi, Yuki
AU - Ogino, Satoyuki
AU - Shimegi, Kenichi
AU - Emura, Hiroyuki
AU - Yonemori, Kyoko
AU - Shimazawa, Akiko
AU - Miura, Gentaro
AU - Hyodo, Ayako
AU - Hyodo, Sari
AU - Nagai, Tunetaka
AU - Funaki, Madoka
AU - Sugihara, Masako
AU - Kita, Mitsuhiro
AU - Yamagata, Bun
AU - Mimura, Masaru
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017
Y1 - 2017
N2 - Background Recent studies have highlighted the clinical usefulness of near-infrared spectroscopy (NIRS) in psychiatry. However, the potential effects of psychotropics on NIRS signals remain unknown. Methods We conducted a systematic chart review of 40 depressed patients who underwent NIRS scans during a verbal fluency task to clarify the relationships between psychotropic dosage and NIRS signals. The dosage of psychotropic medications was calculated using defined daily dose (DDD). We investigated the associations between the DDD of psychotropic medications and oxygenated hemoglobin (oxy-Hb) in single channel levels. Limitations Retrospective study design and small sample size are the main limitations. Results Multiple regression analysis revealed that one channel in the right temporoparietal region had a significant association with antidepressant DDD controlling for age, sex, depression severity, and the DDD of antipsychotics and benzodiazepines. Moreover, high doses of antidepressants had significant effects on NIRS signals compared with low doses, in group comparisons. Conclusions The dose-dependent impact of antidepressants on NIRS signals should be taken into account when interpreting NIRS data.
AB - Background Recent studies have highlighted the clinical usefulness of near-infrared spectroscopy (NIRS) in psychiatry. However, the potential effects of psychotropics on NIRS signals remain unknown. Methods We conducted a systematic chart review of 40 depressed patients who underwent NIRS scans during a verbal fluency task to clarify the relationships between psychotropic dosage and NIRS signals. The dosage of psychotropic medications was calculated using defined daily dose (DDD). We investigated the associations between the DDD of psychotropic medications and oxygenated hemoglobin (oxy-Hb) in single channel levels. Limitations Retrospective study design and small sample size are the main limitations. Results Multiple regression analysis revealed that one channel in the right temporoparietal region had a significant association with antidepressant DDD controlling for age, sex, depression severity, and the DDD of antipsychotics and benzodiazepines. Moreover, high doses of antidepressants had significant effects on NIRS signals compared with low doses, in group comparisons. Conclusions The dose-dependent impact of antidepressants on NIRS signals should be taken into account when interpreting NIRS data.
KW - Antidepressant
KW - Bipolar disorder
KW - Major depressive disorder (MDD)
KW - Near-infrared spectroscopy (NIRS)
KW - Schizophrenia
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U2 - 10.1016/j.nicl.2017.02.008
DO - 10.1016/j.nicl.2017.02.008
M3 - Article
C2 - 28348956
AN - SCOPUS:85015640367
SN - 2213-1582
VL - 14
SP - 648
EP - 655
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
ER -