High myopia and its associated factors in JPHC-NEXT eye study: A cross-sectional observational study

Kiwako Mori, Toshihide Kurihara, Miki Uchino, Hidemasa Torii, Motoko Kawashima, Mariko Sasaki, Yoko Ozawa, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Kenya Yuki, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The increasing prevalence of high myopia has been noted. We investigated the epidemiological characteristics and the related factors of high myopia in a Japanese adult population. Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Eye Study was performed in Chikusei-city, a rural area in mid-east Japan, between 2013 and 2015. A cross-sectional observational analysis was conducted to investigate prevalence and related factors of high myopia. A total of 6101 participants aged ≥40 years without a history of ocular surgeries was included. High myopia was defined as a spherical equivalent refraction of ≤−6.00 diopters according to the American Academy of Ophthalmology. Potential high myopia-related factors included intraocular pressure (IOP), corneal structure, corneal endothelial cell density, age, height, body mass index, heart rate, blood pressure, biochemical profile, and current history of systemic and ocular disorders. The odds ratios of high myopia were estimated using the logistic regression models adjusted for the associated factors. The prevalence of high myopia was 3.8% in males and 5.9% in females with a significant difference. Age was inversely associated, IOP was positively associated, and none of other factors were associated with high myopia in both sexes. In conclusion, only age and IOP were associated with high myopia in this community-based sample.

Original languageEnglish
Article number1788
JournalJournal of Clinical Medicine
Issue number11
Publication statusPublished - 2019 Nov


  • Associated factors
  • High myopia
  • Intraocular pressure

ASJC Scopus subject areas

  • General Medicine


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