Highly diastereo- and enantioselective direct aldol reactions in water

Yujiro Hayashi, Tatsunobu Sumiya, Junichi Takahashi, Hiroaki Gotoh, Tatsuya Urushima, Mitsuru Shoji

Research output: Contribution to journalArticlepeer-review

479 Citations (Scopus)


(Chemical Equation Presented) Going green: The synthetically very important aldol reaction can proceed in water without a metal catalyst with excellent enantioselectivity. The key to the reaction is a small, synthetic organic catalyst based on trans-hydroxyproline with a siloxy group. Thus, this method is an environmentally friendly process for the synthesis of chiral molecules.

Original languageEnglish
Pages (from-to)958-961
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number6
Publication statusPublished - 2006 Jan 30
Externally publishedYes


  • Aldol reaction
  • Asymmetric synthesis
  • Diastereoselectivity
  • Organocatalysis
  • Solvent effects

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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