Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs

Eita Sasaki; Hirotatsu Kojima; Hiroaki Nishimatsu; Yasuteru Urano; Kazuya Kikuchi; Yasunobu Hirata; Tetsuo Nagano

doi:10.1021/ja042967z

Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs

Eita Sasaki, Hirotatsu Kojima, Hiroaki Nishimatsu, Yasuteru Urano, Kazuya Kikuchi, Yasunobu Hirata, Tetsuo Nagano

Research output: Contribution to journal › Article › peer-review

401 Citations (Scopus)

Abstract

Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.

Original language	English
Pages (from-to)	3684-3685
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	11
DOIs	https://doi.org/10.1021/ja042967z
Publication status	Published - 2005 Mar 23
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/ja042967z

Cite this

@article{be7ba091925c4d9fb56c8ff4e8e01156,

title = "Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs",

abstract = "Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.",

author = "Eita Sasaki and Hirotatsu Kojima and Hiroaki Nishimatsu and Yasuteru Urano and Kazuya Kikuchi and Yasunobu Hirata and Tetsuo Nagano",

year = "2005",

month = mar,

day = "23",

doi = "10.1021/ja042967z",

language = "English",

volume = "127",

pages = "3684--3685",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs

AU - Sasaki, Eita

AU - Kojima, Hirotatsu

AU - Nishimatsu, Hiroaki

AU - Urano, Yasuteru

AU - Kikuchi, Kazuya

AU - Hirata, Yasunobu

AU - Nagano, Tetsuo

PY - 2005/3/23

Y1 - 2005/3/23

N2 - Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.

AB - Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.

UR - http://www.scopus.com/inward/record.url?scp=15744383910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15744383910&partnerID=8YFLogxK

U2 - 10.1021/ja042967z

DO - 10.1021/ja042967z

M3 - Article

C2 - 15771488

AN - SCOPUS:15744383910

SN - 0002-7863

VL - 127

SP - 3684

EP - 3685

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 11

ER -

Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this