Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion

Toshifumi Yoshida; Ryuichi Iwakiri; Takahiro Noda; Kazuyo Okamoto; Masataka Kojima; Koji Fukuyama; Kazuma Fujimoto

doi:10.1023/A:1005545801714

Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion

Toshifumi Yoshida, Ryuichi Iwakiri, Takahiro Noda, Kazuyo Okamoto, Masataka Kojima, Koji Fukuyama, Kazuma Fujimoto

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia - reperfusion in the rat intestine. The superior mesenteric artery was occluded for 60 min followed by reperfusion for 60 min. Rats were infused with H₁-receptor antagonist (chlorpheniramine maleate) or H₂-receptor antagonist (cimetidine). Additional rats were pretreated with aminoguanidine (100 mg/kg). Percent apoptosis in the intestinal mucosa increased after reperfusion, but neither H₁ nor H₂ antagonists had any effect on apoptosis. Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. Aminoguanidine attenuated the increase in mucosal apoptosis following reperfusion. Apoptosis induced by an ischemic insult to the intestinal mucosa was not related to an undesirable effect of histamine. Attenuation of increased intestinal apoptosis might be due to increased plasma histamine level and/or other pharmacological action of amioguanidine, including inhibition of inducible nitric oxide synthase.

Original language	English
Pages (from-to)	1138-1144
Number of pages	7
Journal	Digestive Diseases and Sciences
Volume	45
Issue number	6
DOIs	https://doi.org/10.1023/A:1005545801714
Publication status	Published - 2000
Externally published	Yes

Keywords

Aminoguanidine
Diamine oxidase
Fragmented DNA
H-receptor antagonist
H-receptor antagonist
Nitric oxide

ASJC Scopus subject areas

Physiology
Gastroenterology

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10.1023/A:1005545801714

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title = "Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion",

abstract = "This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia - reperfusion in the rat intestine. The superior mesenteric artery was occluded for 60 min followed by reperfusion for 60 min. Rats were infused with H1-receptor antagonist (chlorpheniramine maleate) or H2-receptor antagonist (cimetidine). Additional rats were pretreated with aminoguanidine (100 mg/kg). Percent apoptosis in the intestinal mucosa increased after reperfusion, but neither H1 nor H2 antagonists had any effect on apoptosis. Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. Aminoguanidine attenuated the increase in mucosal apoptosis following reperfusion. Apoptosis induced by an ischemic insult to the intestinal mucosa was not related to an undesirable effect of histamine. Attenuation of increased intestinal apoptosis might be due to increased plasma histamine level and/or other pharmacological action of amioguanidine, including inhibition of inducible nitric oxide synthase.",

keywords = "Aminoguanidine, Diamine oxidase, Fragmented DNA, H-receptor antagonist, H-receptor antagonist, Nitric oxide",

author = "Toshifumi Yoshida and Ryuichi Iwakiri and Takahiro Noda and Kazuyo Okamoto and Masataka Kojima and Koji Fukuyama and Kazuma Fujimoto",

note = "Funding Information: Supported by Grants-in-Aid from the Ministry Education in Japan for Scientific Research 08670601 (to K.F.), 10670487 (to R.I.), and 10470137 (to K.F.).",

year = "2000",

doi = "10.1023/A:1005545801714",

language = "English",

volume = "45",

pages = "1138--1144",

journal = "Digestive Diseases and Sciences",

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TY - JOUR

T1 - Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion

AU - Yoshida, Toshifumi

AU - Iwakiri, Ryuichi

AU - Noda, Takahiro

AU - Okamoto, Kazuyo

AU - Kojima, Masataka

AU - Fukuyama, Koji

AU - Fujimoto, Kazuma

N1 - Funding Information: Supported by Grants-in-Aid from the Ministry Education in Japan for Scientific Research 08670601 (to K.F.), 10670487 (to R.I.), and 10470137 (to K.F.).

PY - 2000

Y1 - 2000

N2 - This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia - reperfusion in the rat intestine. The superior mesenteric artery was occluded for 60 min followed by reperfusion for 60 min. Rats were infused with H1-receptor antagonist (chlorpheniramine maleate) or H2-receptor antagonist (cimetidine). Additional rats were pretreated with aminoguanidine (100 mg/kg). Percent apoptosis in the intestinal mucosa increased after reperfusion, but neither H1 nor H2 antagonists had any effect on apoptosis. Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. Aminoguanidine attenuated the increase in mucosal apoptosis following reperfusion. Apoptosis induced by an ischemic insult to the intestinal mucosa was not related to an undesirable effect of histamine. Attenuation of increased intestinal apoptosis might be due to increased plasma histamine level and/or other pharmacological action of amioguanidine, including inhibition of inducible nitric oxide synthase.

AB - This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia - reperfusion in the rat intestine. The superior mesenteric artery was occluded for 60 min followed by reperfusion for 60 min. Rats were infused with H1-receptor antagonist (chlorpheniramine maleate) or H2-receptor antagonist (cimetidine). Additional rats were pretreated with aminoguanidine (100 mg/kg). Percent apoptosis in the intestinal mucosa increased after reperfusion, but neither H1 nor H2 antagonists had any effect on apoptosis. Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. Aminoguanidine attenuated the increase in mucosal apoptosis following reperfusion. Apoptosis induced by an ischemic insult to the intestinal mucosa was not related to an undesirable effect of histamine. Attenuation of increased intestinal apoptosis might be due to increased plasma histamine level and/or other pharmacological action of amioguanidine, including inhibition of inducible nitric oxide synthase.

KW - Aminoguanidine

KW - Diamine oxidase

KW - Fragmented DNA

KW - H-receptor antagonist

KW - Nitric oxide

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SN - 0163-2116

VL - 45

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JO - Digestive Diseases and Sciences

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Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion

Abstract

Keywords

ASJC Scopus subject areas

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