Histological changes in autoimmune hepatitis with graves’ disease: A child case report

Mamiko Yamada; Hironori Shibata; Yohei Masugi; Tomohiro Ishi; Kaori Kameyama; Hirotoshi Ebinuma; Tomonobu Hasegawa

doi:10.2169/internalmedicine.8417-16

Histological changes in autoimmune hepatitis with graves’ disease: A child case report

Mamiko Yamada, Hironori Shibata, Yohei Masugi, Tomohiro Ishi, Kaori Kameyama, Hirotoshi Ebinuma, Tomonobu Hasegawa

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We herein report a child case of autoimmune hepatitis (AIH) accompanied with Graves’ disease. Elevated aminotransferase levels were found in a 12-year-old Japanese girl with Graves’ disease. In her first liver biopsy, necrosis and inflammation was limited to the centrilobular area, while the second biopsy showed different findings. Namely, portal injury newly appeared, including interface hepatitis, which represents the histological characteristics of AIH. As the histological findings at the onset of AIH do not always show typical findings, a re-biopsy is considered to be important in individuals suspected to have AIH. AIH should be included in the differential diagnosis of liver dysfunction in Graves’ disease, even in children.

Original language	English
Pages (from-to)	2139-2143
Number of pages	5
Journal	Internal Medicine
Volume	56
Issue number	16
DOIs	https://doi.org/10.2169/internalmedicine.8417-16
Publication status	Published - 2017

Keywords

Autoimmune hepatitis
Graves’ disease
Interface hepatitis
Liver histology
Pediatric case

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.8417-16

Cite this

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title = "Histological changes in autoimmune hepatitis with graves{\textquoteright} disease: A child case report",

abstract = "We herein report a child case of autoimmune hepatitis (AIH) accompanied with Graves{\textquoteright} disease. Elevated aminotransferase levels were found in a 12-year-old Japanese girl with Graves{\textquoteright} disease. In her first liver biopsy, necrosis and inflammation was limited to the centrilobular area, while the second biopsy showed different findings. Namely, portal injury newly appeared, including interface hepatitis, which represents the histological characteristics of AIH. As the histological findings at the onset of AIH do not always show typical findings, a re-biopsy is considered to be important in individuals suspected to have AIH. AIH should be included in the differential diagnosis of liver dysfunction in Graves{\textquoteright} disease, even in children.",

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author = "Mamiko Yamada and Hironori Shibata and Yohei Masugi and Tomohiro Ishi and Kaori Kameyama and Hirotoshi Ebinuma and Tomonobu Hasegawa",

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AU - Yamada, Mamiko

AU - Shibata, Hironori

AU - Masugi, Yohei

AU - Ishi, Tomohiro

AU - Kameyama, Kaori

AU - Ebinuma, Hirotoshi

AU - Hasegawa, Tomonobu

PY - 2017

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AB - We herein report a child case of autoimmune hepatitis (AIH) accompanied with Graves’ disease. Elevated aminotransferase levels were found in a 12-year-old Japanese girl with Graves’ disease. In her first liver biopsy, necrosis and inflammation was limited to the centrilobular area, while the second biopsy showed different findings. Namely, portal injury newly appeared, including interface hepatitis, which represents the histological characteristics of AIH. As the histological findings at the onset of AIH do not always show typical findings, a re-biopsy is considered to be important in individuals suspected to have AIH. AIH should be included in the differential diagnosis of liver dysfunction in Graves’ disease, even in children.

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KW - Liver histology

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Histological changes in autoimmune hepatitis with graves’ disease: A child case report

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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