Histological factors contributing to favorable prognoses of soft tissue sarcomas in premenopausal patients

Masahiko Ohsawa, Katsuyuki Aozasa, Akira Myoui, Masaki Q. Fujita, Masahiko Tsujimoto, Takafumi Ueda, Atsumasa Uchida, Keiro Ono, Keishi Matsumoto

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The correlations of sex with various histologic factors in soft tissue sarcomas (STS) were studied in 142 adult patients over the age of 20 years. They included 63 with malignant fibrous histiocytomas, 20 with liposarcomas, 20 with synovial sarcomas, 11 with malignant Schwannomas and 28 with other forms of STS. These were divided into four groups, according to age (20-49 years and ≥50 years) and sex. Survival rates in female patients were better than those in male patients, and the difference was significant between the 20-49 year groups (p<0.01). The relative frequencies in distribution of each histologic type were similar among male and female patients in both age groups. Among histological factors, mitotic counts showed a significant correlation (P< 0.04) with sex, followed by cellularity. STS in female patients aged 20-49 years had lower mitotic counts than in patients in other groups, where it occurred with a higher frequency of low and intermediate grade tumors. The findings suggested estrogen, either directly to indirectly, to have a favorable effect on STS prognosis in premenopausal female patients.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalJapanese journal of clinical oncology
Issue number2
Publication statusPublished - 1991 Apr
Externally publishedYes


  • Estrogen
  • Prognosis
  • Sex
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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