TY - JOUR
T1 - Histological transformation in duodenal-type follicular lymphoma
T2 - A case report and review of the literature
AU - Tanigawa, Tomohiko
AU - Abe, Ryohei
AU - Kato, Jun
AU - Hosoe, Naoki
AU - Ogata, Haruhiko
AU - Kameyama, Kaori
AU - Okamoto, Shinichiro
AU - Mori, Takehiko
N1 - Publisher Copyright:
© 2019 Impact Journals LLC. All rights reserved.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Duodenal-type follicular lymphoma (DFL) is a rare variant of follicular lymphoma (FL) characterized by distinctive clinical features such as localization and favorable prognosis. We herein report a case of DFL in which histological transformation into diffuse large B-cell lymphoma developed 7 years after diagnosis. The transformed lymphoma was refractory to chemotherapy, and the patient passed away due to disease progression. To date, there have been only a limited number of reported cases of histological transformation of DFL, and the clinical outcomes of those cases except our present case have been favorable, with good responses to chemotherapy. Although the histological transformation of DFL is a rare event, the clinical course of the present case suggested that it would be a fatal event and underscore the importance of the life-long management of DFL. Further accumulation of cases is required to elucidate its incidence, characteristics, and prognosis.
AB - Duodenal-type follicular lymphoma (DFL) is a rare variant of follicular lymphoma (FL) characterized by distinctive clinical features such as localization and favorable prognosis. We herein report a case of DFL in which histological transformation into diffuse large B-cell lymphoma developed 7 years after diagnosis. The transformed lymphoma was refractory to chemotherapy, and the patient passed away due to disease progression. To date, there have been only a limited number of reported cases of histological transformation of DFL, and the clinical outcomes of those cases except our present case have been favorable, with good responses to chemotherapy. Although the histological transformation of DFL is a rare event, the clinical course of the present case suggested that it would be a fatal event and underscore the importance of the life-long management of DFL. Further accumulation of cases is required to elucidate its incidence, characteristics, and prognosis.
KW - Chemotherapy
KW - Duodenal-type follicular lymphoma
KW - Duodenum
KW - Histological transformation
KW - Prognosis
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UR - http://www.scopus.com/inward/citedby.url?scp=85066102714&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.26912
DO - 10.18632/oncotarget.26912
M3 - Article
C2 - 31164963
AN - SCOPUS:85066102714
SN - 1949-2553
VL - 10
SP - 3424
EP - 3429
JO - Oncotarget
JF - Oncotarget
IS - 36
ER -