Histopathologic characteristics of gastric ulcers created by endoscopic submucosal dissection

N. Kakushima, M. Fujishiro, S. Kodashima, K. Kobayashi, A. Tateishi, M. Iguchi, A. Imagawa, T. Motoi, N. Yahagi, M. Omata

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


Background and Study Aim: We have previously reported that gastric ulcers artificially created by endoscopic submucosal dissection (ESD) would heal within 8 weeks regardless of size and location. The details of the healing process remain unclear, and we aimed to clarify the mechanism by histopathological investigation. Patients and Methods: 21 post-ESD ulcers were examined histopathologically, using surgically resected specimens from patients who had subsequently undergone gastrectomy due to submucosal invasion and/or lymphovascular infiltration by the tumor. The grade of ulcer, appearance of regenerative mucosa, scar formation, and extent of fibrosis were evaluated. Results: Fibrosis and wall thickening were observed from 2 weeks after ESD, but regenerative mucosa was not observed until 5 weeks. Among 12 patients who underwent gastrectomy later than 8 weeks after ESD, a mucosal defect was still observed in two patients. In these two patients the lesion was associated with severe fibrosis due to previous peptic ulcer or submucosal invasion by the lesion. Conclusion: Size reduction in these ulcers occurs by contraction in the early phase, then regenerative mucosa covers the remaining mucosal defect within 8 weeks. If there is fibrosis under the lesion before ESD, there is a possibility that the artificially created ulcer will not heal within 8 weeks.

Original languageEnglish
Pages (from-to)412-415
Number of pages4
Issue number4
Publication statusPublished - 2006 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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