HIV-2 CRF01-AB: First circulating recombinant form of HIV-2

Shiro Ibe, Yoshiyuki Yokomaku, Teiichiro Shiino, Rie Tanaka, Junko Hattori, Seiichiro Fujisaki, Yasumasa Iwatani, Naoto Mamiya, Makoto Utsumi, Shingo Kato, Motohiro Hamaguchi, Wataru Sugiura

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Background: Five HIV-2-seropositive cases were recently identified in Japan, outside the HIV-2 endemic area of West Africa. To clarify the molecular epidemiology of HIV-2 in Japan, we analyzed sequences of these cases in detail. Methods: HIV-2 genetic groups were determined by gag and env sequences. For suspected recombinant isolates, the genetic structure was determined by full-length genomic analyses. To understand the history and evolution of HIV-2 recombinant isolates, we estimated the time of most recent common ancestor by Bayesian Markov chain Monte Carlo method. Results: Three isolates were determined as recombinants of groups A and B, and their mosaic genome structures were identical with that of 7312A, a recombinant isolate reported in 1990 from Côte dIvoire. Our 3 isolates and 7312A fulfilled the criteria for determining a circulating recombinant form (CRF). These isolates were verified by the Los Alamos HIV sequence database as the first CRF of HIV-2, HIV-2 CRF01-AB. The mean time of most recent common ancestor of CRF01-AB was estimated as between 1964 and 1973, several decades after the estimated emergence of HIV-2. Conclusions: We recently identified HIV-2 CRF01-AB cases in Japan. This ectopic observation of the virus outside its original endemic area suggests an ongoing global spread of HIV-2 CRF01-AB.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number3
Publication statusPublished - 2010 Jul 1
Externally publishedYes


  • CRF01-AB
  • HIV-2
  • circulating recombinant form
  • molecular epidemiology

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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