Ho: YAG laser irradiation in blood vessel as a vasodilator: ex vivo study

E. Nakatani, T. Iwasaki, K. Kaneko, N. Shimazaki, T. Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


We studied Ho:YAG laser irradiation in blood vessel as a vasodilator ex vivo. We thought that the Ho:YAG laser-induced bubble expansion might be able to dilate the vessel because we found the vessel wall expansion after the Ho:YAG laser irradiation, that is steady deformation, in the vessel ex vivo. There have been many reports regarding to the Ho:YAG laser irradiation in the vessel. Most of studies concentrated on the interaction between Ho:YAG laser irradiation and vessel wall to investigate side effect on Ho:YAG laser angioplasty. We proposed to use the Ho: YAG laser-induced bubble expansion as a vasodilator. We studied vasodilation effect of the Ho: YAG laser-induced bubble ex vivo. The flash lamp excited Ho:YAG laser surgical unit (IH102, NIIC, Japan) (λ=2.1μm) was used. The laser energy was delivered by a silica glass fiber (outer diameter: 1000μm, core diameter: 600μm). The laser-induced bubble was generated in the extracted fresh porcine carotid artery with the warmed saline perfusion. The laser energy at the fiber tip was ranging from 170-1300mJ per pulse. Number of the laser irradiation was ranged from 20pulses to 100pulses. The outer diameter of the vessel was observed. To examine the change in mechanical properties of the vessel wall, the stress-strain curve of the laser-irradiated vessel was measured. Birefringence observation and microscopic observation of staining specimen were performed. When the laser energy was set to 1300mJ per pulse, the outer diameter of the vessel after the laser irradiation was expanded by 1.4 times comparing with that of before the laser irradiation and the dilatation effect was kept even at 10minutes after the irradiation. The elasticity modulus of the artery by collagen was changed by the laser irradiation. In the polarized microscopic observation, the brightness of the intimal side of the vessel is increased comparing with that of the normal. We think this brightness increasing may be attributed to birefringence change by the arrangement of stretched collagen fiber. We suppose it is likely to be able to use the Ho:YAG laser irradiation as a temporary vasodilater tool in spite of further study should be performed.

Original languageEnglish
Title of host publicationPhotonic Therapeutics and Diagnostics III
Publication statusPublished - 2007 Aug 31
EventPhotonic Therapeutics and Diagnostics III - San Jose, CA, United States
Duration: 2007 Jan 202007 Jan 21

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherPhotonic Therapeutics and Diagnostics III
Country/TerritoryUnited States
CitySan Jose, CA


  • Acoustic wave
  • Angioplasty
  • Dilatation
  • Ho:YAG laser
  • Laser-induced bubble

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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