Human brain glucose metabolism mapping using multislice 2D 1H-13C correlation HSQC spectroscopy

Hidehiro Watanabe, M. Umeda, Y. Ishihara, K. Okamoto, K. Oshio, T. Kanamatsu, Y. Tsukada

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


A method for multivolume 2D 1H-13C correlation spectroscopy, multislice heteronuclear single quantum coherence (HSQC), is proposed. This permits human brain metabolism from glucose to amino acids to be followed using a 2-T whole-body scanner. The modifications from the conventional HSQC are that the 180°(13C) and 180°(1H) pulses are separated in time in the preparation period and that the 180°(13C) pulse is applied at 1/(4J(CH)) before the 90°(1H) polarization transfer (PT) pulse. The preparation (echo) time can be set longer than 1/(2J(CH)) so that, even in a whole-body system, slice-selective pulses and gradients can be applied. Another modification is that the 90°(1H) reverse PT pulses after the creation of 21(z)S(z) are used as multislice pulses. The time-course of glutamate C4 could be followed with 15-min temporal resolution from the HSQC spectra obtained from the brains of volunteers after the oral administration of glucose C1, and the maximum S/N was 3. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)525-533
Number of pages9
JournalMagnetic Resonance in Medicine
Issue number4
Publication statusPublished - 2000
Externally publishedYes


  • C-MRS
  • H-detection
  • In vivo
  • Mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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