Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Tadahiko Mashino; Kumiko Shimotohno; Noriko Ikegami; Dai Nishikawa; Kensuke Okuda; Kyoko Takahashi; Shigeo Nakamura; Masataka Mochizuki

doi:10.1016/j.bmcl.2004.12.030

Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Tadahiko Mashino, Kumiko Shimotohno, Noriko Ikegami, Dai Nishikawa, Kensuke Okuda, Kyoko Takahashi, Shigeo Nakamura, Masataka Mochizuki

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

171 Citations (Scopus)

Abstract

We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of cationic, anionic, and amino acid-type fullerene derivatives. Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition.

Original language	English
Pages (from-to)	1107-1109
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2004.12.030
Publication status	Published - 2005 Feb 15

Keywords

Anti-HCV
Anti-HIV
Fullerene
RNA-dependent RNA polymerase
Reverse transcriptase

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2004.12.030

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Mashino, T., Shimotohno, K., Ikegami, N., Nishikawa, D., Okuda, K., Takahashi, K., Nakamura, S., & Mochizuki, M. (2005). Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives. Bioorganic and Medicinal Chemistry Letters, 15(4), 1107-1109. https://doi.org/10.1016/j.bmcl.2004.12.030

Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives. / Mashino, Tadahiko; Shimotohno, Kumiko; Ikegami, Noriko et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 4, 15.02.2005, p. 1107-1109.

Research output: Contribution to journal › Article › peer-review

Mashino, T, Shimotohno, K, Ikegami, N, Nishikawa, D, Okuda, K, Takahashi, K, Nakamura, S & Mochizuki, M 2005, 'Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 4, pp. 1107-1109. https://doi.org/10.1016/j.bmcl.2004.12.030

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abstract = "We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of cationic, anionic, and amino acid-type fullerene derivatives. Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition.",

keywords = "Anti-HCV, Anti-HIV, Fullerene, RNA-dependent RNA polymerase, Reverse transcriptase",

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AU - Mashino, Tadahiko

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AU - Nishikawa, Dai

AU - Okuda, Kensuke

AU - Takahashi, Kyoko

AU - Nakamura, Shigeo

AU - Mochizuki, Masataka

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AB - We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of cationic, anionic, and amino acid-type fullerene derivatives. Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition.

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KW - Anti-HIV

KW - Fullerene

KW - RNA-dependent RNA polymerase

KW - Reverse transcriptase

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Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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